cyclopropanecarboxylic acid (2-amino-ethyl)-[cyclohexylcarbamoyl-(2-iodo-phenyl)-methyl]-amide

Base Information

• Chemical Name: cyclopropanecarboxylic acid (2-amino-ethyl)-[cyclohexylcarbamoyl-(2-iodo-phenyl)-methyl]-amide
• CAS No.: 849590-04-1
• Molecular Formula: C₂₀H₂₈IN₃O₂
• Molecular Weight: 469.366

Synonyms:cyclopropanecarboxylic acid (2-amino-ethyl)-[cyclohexylcarbamoyl-(2-iodo-phenyl)-methyl]-amide

Chemical Property of cyclopropanecarboxylic acid (2-amino-ethyl)-[cyclohexylcarbamoyl-(2-iodo-phenyl)-methyl]-amide

Chemical Property:

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Technology Process of cyclopropanecarboxylic acid (2-amino-ethyl)-[cyclohexylcarbamoyl-(2-iodo-phenyl)-methyl]-amide

There total 2 articles about cyclopropanecarboxylic acid (2-amino-ethyl)-[cyclohexylcarbamoyl-(2-iodo-phenyl)-methyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-{[cyclohexylcarbamoyl-(2-iodo-phenyl)-methyl]-cyclopropanecarbonyl-amino}-ethyl)-carbamic acid tert-butyl ester → cyclopropanecarboxylic acid (2-amino-ethyl)-[cyclohexylcarbamoyl-(2-iodo-phenyl)-methyl]-amide (849590-04-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 6h;

DOI:10.1016/j.tetlet.2005.01.063

Reference yield:

2-iodobenzaldehyde (26260-02-6) → cyclopropanecarboxylic acid (2-amino-ethyl)-[cyclohexylcarbamoyl-(2-iodo-phenyl)-methyl]-amide (849590-04-1)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 18 h / 20 °C

2: aq. HCl / dioxane / 6 h / 20 °C

With hydrogenchloride; In 1,4-dioxane; methanol; 1: Ugi reaction;

DOI:10.1016/j.tetlet.2005.01.063

Reference yield: 51.0%

cyclopropanecarboxylic acid (2-amino-ethyl)-[cyclohexylcarbamoyl-(2-iodo-phenyl)-methyl]-amide (849590-04-1) → 2-cyclopropanecarbonyl-6-oxo-1,2,3,4,5,6-hexahydro-benzo[f][1,4]diazocine-1-carboxylic acid cyclohexylamide

Guidance literature:

With palladium diacetate; tributyl-amine; In diethylene glycol dimethyl ether; at 160 ℃; for 1h;

DOI:10.1016/j.tetlet.2005.01.063

upstream raw materials:

2-iodobenzaldehyde

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