(-)-(2R,3R)-2-(4-methoxyphenyl)-3-(4-trifluoromethylphenyl)-1,4-butanediol

Base Information

Chemical Name:(-)-(2R,3R)-2-(4-methoxyphenyl)-3-(4-trifluoromethylphenyl)-1,4-butanediol
CAS No.:474317-50-5
Molecular Formula:C₁₈H₁₉F₃O₃
Molecular Weight:340.342
Hs Code.:

Synonyms:(-)-(2R,3R)-2-(4-methoxyphenyl)-3-(4-trifluoromethylphenyl)-1,4-butanediol

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Chemical Property of (-)-(2R,3R)-2-(4-methoxyphenyl)-3-(4-trifluoromethylphenyl)-1,4-butanediol

Chemical Property:

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Technology Process of (-)-(2R,3R)-2-(4-methoxyphenyl)-3-(4-trifluoromethylphenyl)-1,4-butanediol

There total 4 articles about (-)-(2R,3R)-2-(4-methoxyphenyl)-3-(4-trifluoromethylphenyl)-1,4-butanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: (-)-(R_a,2R,3R)-2-(4-methoxyphenyl)-3-(4-trifluoromethylphenyl)succinic acid [1,1']binaphthalenyl-2,2'-diol ester

: 474317-50-5
(-)-(2R,3R)-2-(4-methoxyphenyl)-3-(4-trifluoromethylphenyl)-1,4-butanediol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/S0957-4166(02)00173-8

Reference yield:

: 104-01-8
4-Methoxyphenylacetic acid

: 474317-50-5
(-)-(2R,3R)-2-(4-methoxyphenyl)-3-(4-trifluoromethylphenyl)-1,4-butanediol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / DCC; DMAP / CH₂Cl₂ / 0 - 25 °C

2.1: 90 percent / DCC; DMAP / CH₂Cl₂ / 0 - 25 °C

3.1: TiCl₄ / CH₂Cl₂ / 0.5 h / -45 °C

3.2: 85 percent / Et₃N / CH₂Cl₂ / 3 h / -45 °C

4.1: 70 percent / LiAlH₄ / tetrahydrofuran / 20 °C

With dmap; lithium aluminium tetrahydride; titanium tetrachloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0957-4166(02)00173-8

Reference yield:

: (R_a)-(4-methoxyphenyl)acetic acid 2'-hydroxy[1,1']binaphthalen-2-yl ester

: 474317-50-5
(-)-(2R,3R)-2-(4-methoxyphenyl)-3-(4-trifluoromethylphenyl)-1,4-butanediol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / DCC; DMAP / CH₂Cl₂ / 0 - 25 °C

2.1: TiCl₄ / CH₂Cl₂ / 0.5 h / -45 °C

2.2: 85 percent / Et₃N / CH₂Cl₂ / 3 h / -45 °C

3.1: 70 percent / LiAlH₄ / tetrahydrofuran / 20 °C

With dmap; lithium aluminium tetrahydride; titanium tetrachloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0957-4166(02)00173-8