(4S,5R)-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-2-morpholino-4-yl)ethyl>oxazolidin-2-one

Base Information

Chemical Name:(4S,5R)-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-2-morpholino-4-yl)ethyl>oxazolidin-2-one
CAS No.:131451-98-4
Molecular Formula:C₁₆H₂₈N₂O₄
Molecular Weight:312.409
Hs Code.:

Synonyms:(4S,5R)-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-2-morpholino-4-yl)ethyl>oxazolidin-2-one

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Chemical Property of (4S,5R)-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-2-morpholino-4-yl)ethyl>oxazolidin-2-one

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Technology Process of (4S,5R)-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-2-morpholino-4-yl)ethyl>oxazolidin-2-one

There total 15 articles about (4S,5R)-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-2-morpholino-4-yl)ethyl>oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 110-91-8,99108-56-2
morpholine

: 104856-26-0
(4S,5R)-4-cyclohexylmethyl-5-<(S)-oxiran-2-yl>oxazolidin-2-one

: 131451-98-4
(4S,5R)-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-2-morpholino-4-yl)ethyl>oxazolidin-2-one

Guidance literature:: In ethanol; for 1h; Heating;
DOI:10.1248/cpb.42.2164

Reference yield: 78.0%

: 131451-96-2
(4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-2-morpholin-4-yl)ethyl>oxazolidin-2-one

: 131451-98-4
(4S,5R)-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-2-morpholino-4-yl)ethyl>oxazolidin-2-one

Guidance literature:: With ammonia; sodium; at -78 ℃; for 2h;
DOI:10.1246/cl.1990.1709

Reference yield:

: 139056-96-5,139164-19-5
(4R,5R)-4-<(S)-(1-(N-Benzyl-N-methoxycarbonyl)amino-2-cyclohexyl)ethyl>-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane

: 131451-98-4
(4S,5R)-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-2-morpholino-4-yl)ethyl>oxazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 80percent AcOH / 5 h / 80 °C

2: KOH / methanol / 3.5 h / Ambient temperature

3: 96 percent / pyridine / 3 h / 0 °C

4: 98 percent / H₂ / 20percent Pd(OH)2/C / methanol / 48 h / 760 Torr / Ambient temperature

5: 94 percent / NaOMe / tetrahydrofuran / 0.5 h / 0 °C

6: 94 percent / methanol / 24 h / Ambient temperature

7: 78 percent / Na, liq. NH₃ / diethyl ether / 2 h / -78 °C

With pyridine; potassium hydroxide; ammonia; hydrogen; sodium methylate; sodium; acetic acid; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1248/cpb.39.2550