(S)-2-[[(tert-Butyloxy)carbonyl]amino]-3-phenyl-1-propanesulfinic acid chloride

Base Information

Chemical Name:(S)-2-[[(tert-Butyloxy)carbonyl]amino]-3-phenyl-1-propanesulfinic acid chloride
CAS No.:145641-39-0
Molecular Formula:C₁₄H₂₀ClNO₃S
Molecular Weight:317.837
Hs Code.:
DSSTox Substance ID:DTXSID001142263
Nikkaji Number:J681.068C

Synonyms:DTXSID001142263;(S)-2-[[(tert-Butyloxy)carbonyl]amino]-3-phenyl-1-propanesulfinic acid chloride;1,1-Dimethylethyl N-[(1S)-1-[(chlorosulfinyl)methyl]-2-phenylethyl]carbamate;145641-39-0

Suppliers and Price of (S)-2-[[(tert-Butyloxy)carbonyl]amino]-3-phenyl-1-propanesulfinic acid chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-[[(tert-Butyloxy)carbonyl]amino]-3-phenyl-1-propanesulfinic acid chloride

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:317.0852424
Heavy Atom Count:20
Complexity:338

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(CC1=CC=CC=C1)CS(=O)Cl
Isomeric SMILES:CC(C)(C)OC(=O)N[C@@H](CC1=CC=CC=C1)CS(=O)Cl

Technology Process of (S)-2-[[(tert-Butyloxy)carbonyl]amino]-3-phenyl-1-propanesulfinic acid chloride

There total 6 articles about (S)-2-[[(tert-Butyloxy)carbonyl]amino]-3-phenyl-1-propanesulfinic acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122818-32-0
(S)-2-<(tert-Butoxycarbonyl)amino>-3-phenylpropyl thioacetate

: 145641-39-0
((S)-1-Chlorosulfinylmethyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: With acetic anhydride; chlorine;
DOI:10.1016/S0040-4039(00)60981-4

Reference yield:

: 66605-57-0
(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

: 145641-39-0
((S)-1-Chlorosulfinylmethyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / Et₃N

2: 93 percent / Cs₂CO₃ / dimethylformamide / Ambient temperature

3: Ac₂O, Cl₂ / CH₂Cl₂ / 1 h / -18 - -10 °C

With acetic anhydride; chlorine; caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00121a038

Reference yield:

: 126301-19-7,134807-64-0,109687-66-3
(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropyl methanesulfonate

: 145641-39-0
((S)-1-Chlorosulfinylmethyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / Cs₂CO₃ / dimethylformamide / Ambient temperature

2: Ac₂O, Cl₂ / CH₂Cl₂ / 1 h / -18 - -10 °C

With acetic anhydride; chlorine; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00121a038