(6aR,7S,9aS,11S,13aS)-2-(3,4-dimethoxybenzyl)-11-hydroxy-5-methoxy-6a,7,10,10-tetramethyl-2,3,6,6a,7,8,9,9a,10,11,12,13-dodecahydro-1H-benzo[8,8a][1]benzopyrano[2,3-e]isoindol-3-one

Base Information

Chemical Name:(6aR,7S,9aS,11S,13aS)-2-(3,4-dimethoxybenzyl)-11-hydroxy-5-methoxy-6a,7,10,10-tetramethyl-2,3,6,6a,7,8,9,9a,10,11,12,13-dodecahydro-1H-benzo[8,8a][1]benzopyrano[2,3-e]isoindol-3-one
CAS No.:1236125-85-1
Molecular Formula:C₃₃H₄₃NO₆
Molecular Weight:549.708
Hs Code.:

(6aR,7S,9aS,11S,13aS)-2-(3,4-dimethoxybenzyl)-11-hydroxy-5-methoxy-6a,7,10,10-tetramethyl-2,3,6,6a,7,8,9,9a,10,11,12,13-dodecahydro-1H-benzo[8,8a][1]benzopyrano[2,3-e]isoindol-3-one

Synonyms:(6aR,7S,9aS,11S,13aS)-2-(3,4-dimethoxybenzyl)-11-hydroxy-5-methoxy-6a,7,10,10-tetramethyl-2,3,6,6a,7,8,9,9a,10,11,12,13-dodecahydro-1H-benzo[8,8a][1]benzopyrano[2,3-e]isoindol-3-one

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Chemical Property of (6aR,7S,9aS,11S,13aS)-2-(3,4-dimethoxybenzyl)-11-hydroxy-5-methoxy-6a,7,10,10-tetramethyl-2,3,6,6a,7,8,9,9a,10,11,12,13-dodecahydro-1H-benzo[8,8a][1]benzopyrano[2,3-e]isoindol-3-one

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Technology Process of (6aR,7S,9aS,11S,13aS)-2-(3,4-dimethoxybenzyl)-11-hydroxy-5-methoxy-6a,7,10,10-tetramethyl-2,3,6,6a,7,8,9,9a,10,11,12,13-dodecahydro-1H-benzo[8,8a][1]benzopyrano[2,3-e]isoindol-3-one

There total 22 articles about (6aR,7S,9aS,11S,13aS)-2-(3,4-dimethoxybenzyl)-11-hydroxy-5-methoxy-6a,7,10,10-tetramethyl-2,3,6,6a,7,8,9,9a,10,11,12,13-dodecahydro-1H-benzo[8,8a][1]benzopyrano[2,3-e]isoindol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1236125-83-9
(6aR,7S,9aS,11R,13aS)-2-(3,4-dimethoxybenzyl)-5-methoxy-6a,7,10,10-tetramethyl-2,3,6,6a,7,8,9,9a,10,11,12,13-dodecahydro-1H-benzo[8,8a][1]benzopyrano[2,3-e]isoindol-3,11-dione

: 1236125-85-1
(6aR,7S,9aS,11S,13aS)-2-(3,4-dimethoxybenzyl)-11-hydroxy-5-methoxy-6a,7,10,10-tetramethyl-2,3,6,6a,7,8,9,9a,10,11,12,13-dodecahydro-1H-benzo[8,8a][1]benzopyrano[2,3-e]isoindol-3-one

Guidance literature:: With lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; at -20 ℃; stereoselective reaction;
DOI:10.1039/c000193g

Reference yield: 66.0%

: 2-(3,4-dimethoxybenzyl)-4-hydroxy-6-methoxy-5-{[(1aRS,3aS,4R,5S,7aS,7bSR)-4,5,7a,7b-tetramethyldecahydronaphtho[2,1-b]oxiren-4-yl]methyl}isoindolin-1-one

: 1236125-81-7
(6aR,7S,9aS,11R,13aS)-2-(3,4-dimethoxybenzyl)-11-hydroxy-5-methoxy-6a,7,10,10-tetramethyl-2,3,6,6a,7,8,9,9a,10,11,12,13-dodecahydro-1H-benzo[8,8a][1]benzopyrano[2,3-e]isoindol-3-one

: 1236125-85-1
(6aR,7S,9aS,11S,13aS)-2-(3,4-dimethoxybenzyl)-11-hydroxy-5-methoxy-6a,7,10,10-tetramethyl-2,3,6,6a,7,8,9,9a,10,11,12,13-dodecahydro-1H-benzo[8,8a][1]benzopyrano[2,3-e]isoindol-3-one

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at -40 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1039/c000193g

Reference yield: 62.0%

: C₄₂H₅₃NO₇

: 1236125-85-1
(6aR,7S,9aS,11S,13aS)-2-(3,4-dimethoxybenzyl)-11-hydroxy-5-methoxy-6a,7,10,10-tetramethyl-2,3,6,6a,7,8,9,9a,10,11,12,13-dodecahydro-1H-benzo[8,8a][1]benzopyrano[2,3-e]isoindol-3-one

Guidance literature:: C₄₂H₅₃NO₇; With hydrogenchloride; methanol; In dichloromethane;

With boron trifluoride diethyl etherate; In dichloromethane; at -40 - -15 ℃; Inert atmosphere;

With palladium on activated charcoal; hydrogen; In ethanol;
DOI:10.1016/j.tet.2018.02.048