tert-butyl 2-oxo-3-(3-oxopropyl)-3-phenylindoline-1-carboxylate

Base Information

• Chemical Name: tert-butyl 2-oxo-3-(3-oxopropyl)-3-phenylindoline-1-carboxylate
• CAS No.: 1451091-11-4
• Molecular Formula: C₂₂H₂₃NO₄
• Molecular Weight: 365.429
• Mol file: 1451091-11-4.mol

Synonyms:tert-butyl 2-oxo-3-(3-oxopropyl)-3-phenylindoline-1-carboxylate

Chemical Property of tert-butyl 2-oxo-3-(3-oxopropyl)-3-phenylindoline-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-oxo-3-(3-oxopropyl)-3-phenylindoline-1-carboxylate

There total 1 articles about tert-butyl 2-oxo-3-(3-oxopropyl)-3-phenylindoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

tert-butyl 2-oxo-3-phenylindoline-1-carboxylate (862906-97-6) + acrolein (107-02-8,25068-14-8) → tert-butyl 2-oxo-3-(3-oxopropyl)-3-phenylindoline-1-carboxylate (1451091-11-4)

Guidance literature:

tert-butyl 2-oxo-3-phenylindoline-1-carboxylate; With diphenyl(methyl)phosphine; In chloroform; at 20 ℃;

acrolein; In chloroform; at 20 ℃; for 0.0833333h;

DOI:10.1002/anie.201208285

Reference yield: 100.0%

tert-butyl 2-oxo-3-(3-oxopropyl)-3-phenylindoline-1-carboxylate (1451091-11-4) → C22H23NO5

Guidance literature:

With sodium chlorite; sodium dihydrogen phosphate monohydrate; tert-butyl alcohol; In water; at 0 - 20 ℃; for 1h;

DOI:10.1002/asia.201402194

Reference yield:

tert-butyl 2-oxo-3-(3-oxopropyl)-3-phenylindoline-1-carboxylate (1451091-11-4) → C22H23N5O4

Guidance literature:

Multi-step reaction with 2 steps

1.1: tert-butyl alcohol; sodium dihydrogen phosphate monohydrate; sodium chlorite / water / 1 h / 0 - 20 °C

2.1: diphenyl phosphoryl azide; triethylamine / toluene / 1 h / 100 °C

2.2: 12 h / 80 °C

With sodium chlorite; sodium dihydrogen phosphate monohydrate; diphenyl phosphoryl azide; triethylamine; tert-butyl alcohol; In water; toluene;

DOI:10.1002/asia.201402194

upstream raw materials:

tert-butyl 2-oxo-3-phenylindoline-1-carboxylate

acrolein

Downstream raw materials:

C₂₁H₂₄N₂O₃