(6S)-3-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Base Information

Chemical Name:(6S)-3-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
CAS No.:1131004-99-3
Molecular Formula:C₁₄H₁₂F₃N₃O₅
Molecular Weight:359.262
Hs Code.:

Synonyms:(6S)-3-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Suppliers and Price of (6S)-3-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (6S)-3-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Chemical Property:

Purity/Quality:: 95%+ or 98%+ ^*data from raw suppliers

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Technology Process of (6S)-3-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

There total 6 articles about (6S)-3-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1163680-85-0
(6S)-3-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol

: 50824-05-0
4-trifluoromethoxybenzyl bromide

: 1131004-99-3
(6S)-3-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 2.5h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.7b00356

Reference yield:

: 1105632-57-2
(6S)-6-((tetrahydro-2H-pyran-2-yl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

: 1131004-99-3
(6S)-3-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; water / methanol / 15 h / 20 °C

2.1: trifluoroacetic anhydride / 0.25 h / -5 - 0 °C

2.2: 3 h / -50 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2.5 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; water; sodium hydride; trifluoroacetic anhydride; In methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acsmedchemlett.7b00356

Reference yield:

: 1105632-61-8
(6S)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol

: 1131004-99-3
(6S)-3-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic anhydride / 0.25 h / -5 - 0 °C

1.2: 3 h / -50 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2.5 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; trifluoroacetic anhydride; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acsmedchemlett.7b00356