Sodium; (S)-4-{[2-cyclopropyl-4-(4-fluoro-phenyl)-6-phenyl-pyridin-3-ylmethoxy]-hydroxy-phosphoryl}-3-hydroxy-butyrate

Base Information

Chemical Name:Sodium; (S)-4-{[2-cyclopropyl-4-(4-fluoro-phenyl)-6-phenyl-pyridin-3-ylmethoxy]-hydroxy-phosphoryl}-3-hydroxy-butyrate
CAS No.:135426-91-4
Molecular Formula:C₂₅H₂₃FNO₆P*2Na
Molecular Weight:529.412
Hs Code.:

Synonyms:Sodium; (S)-4-{[2-cyclopropyl-4-(4-fluoro-phenyl)-6-phenyl-pyridin-3-ylmethoxy]-hydroxy-phosphoryl}-3-hydroxy-butyrate

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Chemical Property of Sodium; (S)-4-{[2-cyclopropyl-4-(4-fluoro-phenyl)-6-phenyl-pyridin-3-ylmethoxy]-hydroxy-phosphoryl}-3-hydroxy-butyrate

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Technology Process of Sodium; (S)-4-{[2-cyclopropyl-4-(4-fluoro-phenyl)-6-phenyl-pyridin-3-ylmethoxy]-hydroxy-phosphoryl}-3-hydroxy-butyrate

There total 8 articles about Sodium; (S)-4-{[2-cyclopropyl-4-(4-fluoro-phenyl)-6-phenyl-pyridin-3-ylmethoxy]-hydroxy-phosphoryl}-3-hydroxy-butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-4-{[2-Cyclopropyl-4-(4-fluoro-phenyl)-6-phenyl-pyridin-3-ylmethoxy]-methoxy-phosphoryl}-3-hydroxy-butyric acid methyl ester

: 135426-91-4
Sodium; (S)-4-{[2-cyclopropyl-4-(4-fluoro-phenyl)-6-phenyl-pyridin-3-ylmethoxy]-hydroxy-phosphoryl}-3-hydroxy-butyrate

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 55 ℃; for 3h;
DOI:10.1021/jm00113a019

Reference yield:

: 1608-51-1
4-fluorochalcone

: 135426-91-4
Sodium; (S)-4-{[2-cyclopropyl-4-(4-fluoro-phenyl)-6-phenyl-pyridin-3-ylmethoxy]-hydroxy-phosphoryl}-3-hydroxy-butyrate

Guidance literature:: Multi-step reaction with 6 steps

1: EtONa / ethanol / 4.5 h / Ambient temperature

2: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

3: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

4: pyridine / 16 h / 0 °C

5: HOAc, tetra-n-butylammonium fluoride / tetrahydrofuran / 19 h / Ambient temperature

6: 1N aq. NaOH / dioxane / 3 h / 55 °C

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; copper diacetate; ammonium acetate; tetrabutyl ammonium fluoride; sodium ethanolate; acetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; acetic acid;
DOI:10.1021/jm00113a019

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 135426-91-4
Sodium; (S)-4-{[2-cyclopropyl-4-(4-fluoro-phenyl)-6-phenyl-pyridin-3-ylmethoxy]-hydroxy-phosphoryl}-3-hydroxy-butyrate

Guidance literature:: Multi-step reaction with 7 steps

1: EtONa / ethanol / 16 h / Ambient temperature

2: EtONa / ethanol / 4.5 h / Ambient temperature

3: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

4: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

5: pyridine / 16 h / 0 °C

6: HOAc, tetra-n-butylammonium fluoride / tetrahydrofuran / 19 h / Ambient temperature

7: 1N aq. NaOH / dioxane / 3 h / 55 °C

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; copper diacetate; ammonium acetate; tetrabutyl ammonium fluoride; sodium ethanolate; acetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; acetic acid;
DOI:10.1021/jm00113a019