benzyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate

Base Information

Chemical Name:benzyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate
CAS No.:1566584-34-6
Molecular Formula:C₃₂H₃₄N₆O₃
Molecular Weight:550.66
Hs Code.:

Synonyms:benzyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate

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Chemical Property of benzyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate

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Technology Process of benzyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate

There total 12 articles about benzyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1566651-77-1
2-(2-(2-(2-((4-(4-((benzyloxy)carbonyl)piperazin-1-yl)phenyl)amino)pyrimidine-4-yl)ethyl)phenyl)acetic acid

: 1566584-34-6
benzyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate

Guidance literature:: 2-(2-(2-(2-((4-(4-((benzyloxy)carbonyl)piperazin-1-yl)phenyl)amino)pyrimidine-4-yl)ethyl)phenyl)acetic acid; With N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

With ammonium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 947673-13-4
benzyl 4-(4-nitrophenyl)piperazine-1-carboxylate

: 1566584-34-6
benzyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: cobalt(II) chloride; sodium tetrahydroborate; methanol / 1 h / 0 °C

2.1: trifluoroacetic acid / 2,2,2-trifluoroethanol / 2 h / 100 - 150 °C / Microwave irradiation

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

4.2: 18 h / 20 °C

With methanol; sodium tetrahydroborate; lithium hydroxide monohydrate; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; water; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; cobalt(II) chloride; In tetrahydrofuran; methanol; 2,2,2-trifluoroethanol; N,N-dimethyl-formamide;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1566584-34-6
benzyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C

2.1: cobalt(II) chloride; sodium tetrahydroborate; methanol / 1 h / 0 °C

3.1: trifluoroacetic acid / 2,2,2-trifluoroethanol / 2 h / 100 - 150 °C / Microwave irradiation

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 16 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

5.2: 18 h / 20 °C

With methanol; sodium tetrahydroborate; lithium hydroxide monohydrate; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; water; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; cobalt(II) chloride; In tetrahydrofuran; methanol; 2,2,2-trifluoroethanol; N,N-dimethyl-formamide;