trans-(1-Benzylpyrrolidine-2,5-diyl)dimethanol

Base Information

Chemical Name:trans-(1-Benzylpyrrolidine-2,5-diyl)dimethanol
CAS No.:93713-36-1
Molecular Formula:C₁₃H₁₉NO₂
Molecular Weight:221.299
Hs Code.:
DSSTox Substance ID:DTXSID601230313
Nikkaji Number:J1.530.310G

Synonyms:93713-36-1;2,5-Pyrrolidinedimethanol, 1-(phenylmethyl)-, (2R,5R)-;[(2R,5R)-1-Benzyl-5-(hydroxymethyl)pyrrolidin-2-yl]methanol;(trans)-1-Benzylpyrrolidine-2,5-diyl)dimethanol;trans-(1-Benzylpyrrolidine-2,5-diyl)dimethanol;DTXSID601230313;1-Benzylpyrrolidine-2beta,5alpha-dimethanol;A883490;(2R,5R)-1-(Phenylmethyl)-2,5-pyrrolidinedimethanol

Suppliers and Price of trans-(1-Benzylpyrrolidine-2,5-diyl)dimethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
(trans)-1-Benzylpyrrolidine-2,5-diyl)dimethanol
1g
$ 1758.00

Total 4 raw suppliers

Chemical Property of trans-(1-Benzylpyrrolidine-2,5-diyl)dimethanol

Chemical Property:

XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:221.141578849
Heavy Atom Count:16
Complexity:192

Purity/Quality:

95%-98% ^*data from raw suppliers

(trans)-1-Benzylpyrrolidine-2,5-diyl)dimethanol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(N(C1CO)CC2=CC=CC=C2)CO
Isomeric SMILES:C1C[C@@H](N([C@H]1CO)CC2=CC=CC=C2)CO

Technology Process of trans-(1-Benzylpyrrolidine-2,5-diyl)dimethanol

There total 14 articles about trans-(1-Benzylpyrrolidine-2,5-diyl)dimethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 157182-26-8
(+)-(2R,5R)-N-benzyl-2,5-bis(acetoxymethyl)pyrrolidine

: 93713-36-1
1-Benzyl-[(2R,5R)-2,5-bis(hydroxymethyl)]pyrrolidine

Guidance literature:: With potassium carbonate; In methanol; water;
DOI:10.1016/S0040-4039(00)73281-3

Reference yield:

: 204120-35-4
(2R,5R)-1-Benzyl-2,5-bis-methoxymethoxymethyl-pyrrolidine

: 93713-36-1
1-Benzyl-[(2R,5R)-2,5-bis(hydroxymethyl)]pyrrolidine

Guidance literature:: With hydrogenchloride; In methanol; at 80 ℃; for 48h;
DOI:10.1039/b100961n

Reference yield:

: 24211-51-6
(2S,5S)-hexane-1,2,5,6-tetrol

: 93713-36-1
1-Benzyl-[(2R,5R)-2,5-bis(hydroxymethyl)]pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / imidazole / dimethylformamide / 1) 0 deg C, 1 h, 2) r.t., overnight

2: 89.7 percent / TEA / CH₂Cl₂ / 18 h / 5 °C

3: 3percent HCl / methanol / 16 h

4: 0.5 h / 80 °C

With 1H-imidazole; hydrogenchloride; TEA; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)89042-6