C₄₇H₅₇IN₂O₉Si

Base Information

Chemical Name:C₄₇H₅₇IN₂O₉Si
CAS No.:1414948-95-0
Molecular Formula:C₄₇H₅₇IN₂O₉Si
Molecular Weight:948.968
Hs Code.:

C<sub>47</sub>H<sub>57</sub>IN<sub>2</sub>O<sub>9</sub>Si

Synonyms:C₄₇H₅₇IN₂O₉Si

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Chemical Property of C₄₇H₅₇IN₂O₉Si

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Technology Process of C₄₇H₅₇IN₂O₉Si

There total 22 articles about C₄₇H₅₇IN₂O₉Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1414948-82-5
(3R,5R,6R,12S,12aS)-2-chloroethyl 7-(benzyloxy)-3-[6-(benzyloxy)-7-methylbenzo[d][1,3]dioxol-4-yl]-5-{[(tert-butyldimethylsilyl)oxy]methyl}-8-methoxy-9-methyl-3,5,6,11,12,12a-hexahydro-2H-6,12-epiminobenzo[e]oxazolo[3,2-a]azocine-13-carboxylate

: 1414948-95-0
C₄₇H₅₇IN₂O₉Si

Guidance literature:: With sodium iodide; In N,N-dimethyl-formamide; at 110 ℃; for 18h;
DOI:10.1055/s-0032-1316579

Reference yield:

: 1414948-46-1
(S)-5-(2-amino-3,3-dimethoxypropyl)-2-methoxy-3-methylphenol

: 1414948-95-0
C₄₇H₅₇IN₂O₉Si

Guidance literature:: Multi-step reaction with 14 steps

1: formic acid; sodium sulfate / dichloromethane / 24 h / 0 - 20 °C

2: potassium carbonate / acetone / 41.5 h / 0 - 20 °C

3: pyridine / dichloromethane / 1 h / 0 - 20 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene; 2-hydroxyethanethiol / acetonitrile / 2 h / 0 - 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 23.5 h / 0 - 20 °C

6: N-Bromosuccinimide / dichloromethane / 0.5 h / 0 °C

7: trifluoroacetic acid / dichloromethane / 0.42 h / 0 °C

8: pyridine / dichloromethane / 0.5 h / 0 °C

9: triethylamine / 1 h / 20 °C

10: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

11: sodium tetrahydroborate; lithium chloride / tetrahydrofuran; ethanol / 48 h / 0 - 20 °C

12: boron trifluoride diethyl etherate / dichloromethane / 1.92 h / 0 °C

13: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 0 °C / Reflux

14: sodium iodide / N,N-dimethyl-formamide / 18 h / 110 °C

With pyridine; 1H-imidazole; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; N-Bromosuccinimide; formic acid; boron trifluoride diethyl etherate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium sulfate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 2-hydroxyethanethiol; sodium iodide; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile; 1: |Pictet-Spengler Synthesis;
DOI:10.1055/s-0032-1316579

Reference yield:

: 575444-12-1
3-(benzyloxy)-4-methoxy-5-methylbenzaldehyde

: 1414948-95-0
C₄₇H₅₇IN₂O₉Si

Guidance literature:: Multi-step reaction with 23 steps

1.1: N,N,N',N'-tetramethylguanidine / dichloromethane / 48 h / 20 °C

2.1: (+)-1,2-bis-[(2S,5S)-2,5-diethylphospholano]benzene (1,5-cycloctadiene)rhodium(I) trifluoromethanesulfonate; hydrogen / ethyl acetate / 72 h / 50 °C / 25858.1 Torr

3.1: methanol; acetyl chloride / 0 - 20 °C

4.1: triethylamine / dichloromethane / 0 - 20 °C

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0 - 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 24 h / 0 - 20 °C

7.1: diisobutylaluminium hydride / toluene / 1.5 h / -78 °C / Inert atmosphere

7.2: 1 h / 20 °C

8.1: water; toluene-4-sulfonic acid / methanol / 1.5 h / 20 °C / Reflux

9.1: 10% Pd/C; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr

10.1: formic acid; sodium sulfate / dichloromethane / 24 h / 0 - 20 °C

11.1: potassium carbonate / acetone / 41.5 h / 0 - 20 °C

12.1: pyridine / dichloromethane / 1 h / 0 - 20 °C

13.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; 2-hydroxyethanethiol / acetonitrile / 2 h / 0 - 20 °C

14.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 23.5 h / 0 - 20 °C

15.1: N-Bromosuccinimide / dichloromethane / 0.5 h / 0 °C

16.1: trifluoroacetic acid / dichloromethane / 0.42 h / 0 °C

17.1: pyridine / dichloromethane / 0.5 h / 0 °C

18.1: triethylamine / 1 h / 20 °C

19.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

20.1: sodium tetrahydroborate; lithium chloride / tetrahydrofuran; ethanol / 48 h / 0 - 20 °C

21.1: boron trifluoride diethyl etherate / dichloromethane / 1.92 h / 0 °C

22.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 0 °C / Reflux

23.1: sodium iodide / N,N-dimethyl-formamide / 18 h / 110 °C

With pyridine; 1H-imidazole; methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; N-Bromosuccinimide; formic acid; (+)-1,2-bis-[(2S,5S)-2,5-diethylphospholano]benzene (1,5-cycloctadiene)rhodium(I) trifluoromethanesulfonate; 10% Pd/C; boron trifluoride diethyl etherate; water; hydrogen; diisobutylaluminium hydride; potassium carbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; acetyl chloride; trifluoroacetic acid; 2-hydroxyethanethiol; sodium iodide; lithium chloride; lithium hydroxide; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; 1.1: |Horner-Wadsworth-Emmons Olefination / 10.1: |Pictet-Spengler Synthesis;
DOI:10.1055/s-0032-1316579