(S)-3-(5-methyl-4-phenyl-1H-imidazol-2-yl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(S)-3-(5-methyl-4-phenyl-1H-imidazol-2-yl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:781662-35-9
Molecular Formula:C₁₉H₁₉N₃
Molecular Weight:289.38
Hs Code.:

Synonyms:(S)-3-(5-methyl-4-phenyl-1H-imidazol-2-yl)-1,2,3,4-tetrahydroisoquinoline

Suppliers and Price of (S)-3-(5-methyl-4-phenyl-1H-imidazol-2-yl)-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(5-methyl-4-phenyl-1H-imidazol-2-yl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of (S)-3-(5-methyl-4-phenyl-1H-imidazol-2-yl)-1,2,3,4-tetrahydroisoquinoline

There total 1 articles about (S)-3-(5-methyl-4-phenyl-1H-imidazol-2-yl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 422572-66-5
(S)-3-(5-methyl-4-phenyl-1H-imidazol-2-yl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

: 781662-35-9
(S)-3-(5-methyl-4-phenyl-1H-imidazol-2-yl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With trifluoroacetic acid; at 0 - 20 ℃;
DOI:10.1021/jm030548r

Reference yield:

: 47375-34-8
Boc-Tyr(t-Bu)-OH

: 781662-35-9
(S)-3-(5-methyl-4-phenyl-1H-imidazol-2-yl)-1,2,3,4-tetrahydroisoquinoline

: {(1S)-1-(4-tert-butoxybenzyl)-2-[(3R)-3-(4-methyl-5-phenyl-1H-imidazol-2-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-2-oxo-ethyl}carbamic acid tert-butyl ester

: 422572-67-6
{(1S)-1-(4-tert-butoxybenzyl)-2-[(3S)-3-(4-methyl-5-phenyl-1H-imidazol-2-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-2-oxo-ethyl}carbamic acid tert-butyl ester

Guidance literature:: Boc-Tyr(t-Bu)-OH; With 4-methyl-morpholine; isobutyl chloroformate; In dichloromethane; at 0 ℃;

(S)-3-(5-methyl-4-phenyl-1H-imidazol-2-yl)-1,2,3,4-tetrahydroisoquinoline; In dichloromethane;
DOI:10.1021/jm030548r

Reference yield:

: 781662-35-9
(S)-3-(5-methyl-4-phenyl-1H-imidazol-2-yl)-1,2,3,4-tetrahydroisoquinoline

: (2S)-2-amino-3-(4-hydroxyphenyl)-1-[(3R)-3-(5-methyl-4-phenyl-1H-imidazol-2-yl)-3,4-dihydro-1H-isoquinolin-2-yl]propan-1-one bis-trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-methylmorpholine; isobutyl chloroformate / CH₂Cl₂ / 0 °C

1.2: 50 mg / CH₂Cl₂

2.1: 47 percent / 0 °C

With 4-methyl-morpholine; isobutyl chloroformate; In dichloromethane;
DOI:10.1021/jm030548r