4-[4-(3-cyclopentylpropyl)-5-oxo-4,5-dihydrotetrazol-1-yl]-N-[4-(4-oxopiperidin-1-yl)phenyl]benzenesulfonamide

Base Information

• Chemical Name: 4-[4-(3-cyclopentylpropyl)-5-oxo-4,5-dihydrotetrazol-1-yl]-N-[4-(4-oxopiperidin-1-yl)phenyl]benzenesulfonamide
• CAS No.: 373359-55-8
• Molecular Formula: C₂₆H₃₂N₆O₄S
• Molecular Weight: 524.644
• Mol file: 373359-55-8.mol

Synonyms:4-[4-(3-cyclopentylpropyl)-5-oxo-4,5-dihydrotetrazol-1-yl]-N-[4-(4-oxopiperidin-1-yl)phenyl]benzenesulfonamide

Chemical Property of 4-[4-(3-cyclopentylpropyl)-5-oxo-4,5-dihydrotetrazol-1-yl]-N-[4-(4-oxopiperidin-1-yl)phenyl]benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-[4-(3-cyclopentylpropyl)-5-oxo-4,5-dihydrotetrazol-1-yl]-N-[4-(4-oxopiperidin-1-yl)phenyl]benzenesulfonamide

There total 2 articles about 4-[4-(3-cyclopentylpropyl)-5-oxo-4,5-dihydrotetrazol-1-yl]-N-[4-(4-oxopiperidin-1-yl)phenyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

4-[(3-cyclopentylpropyl)-5-oxo-4,5-dihydrotetrazol-1-yl]phenylsulfonyl chloride (182251-92-9) + 1-(4-aminophenyl)piperidin-4-one hydrochloride → 4-[4-(3-cyclopentylpropyl)-5-oxo-4,5-dihydrotetrazol-1-yl]-N-[4-(4-oxopiperidin-1-yl)phenyl]benzenesulfonamide (373359-55-8)

Guidance literature:

With triethylamine; In 1,4-dioxane; for 24h;

DOI:10.1016/S0968-0896(01)00114-6

Reference yield:

4-[(3-cyclopentylpropyl)-5-oxo-4,5-dihydrotetrazol-1-yl]phenylsulfonyl chloride (182251-92-9) + 1-(4-amino-phenyl)-piperidin-4-one (170011-70-8) → 4-[4-(3-cyclopentylpropyl)-5-oxo-4,5-dihydrotetrazol-1-yl]-N-[4-(4-oxopiperidin-1-yl)phenyl]benzenesulfonamide (373359-55-8)

Guidance literature:

Reference yield: 46.0%

N-[5-(2-Amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide (13698-56-1) + 4-[4-(3-cyclopentylpropyl)-5-oxo-4,5-dihydrotetrazol-1-yl]-N-[4-(4-oxopiperidin-1-yl)phenyl]benzenesulfonamide (373359-55-8) → 4-[4-(3-cyclopentylpropyl)-5-oxo-4,5-dihydro-1H-tetraazol-1-yl]-N-(4-{4-[(2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}phenyl)benzenesulfonamide

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 258.574 - 1034.3 Torr;

DOI:10.1016/S0968-0896(01)00114-6

upstream raw materials:

4-[(3-cyclopentylpropyl)-5-oxo-4,5-dihydrotetrazol-1-yl]phenylsulfonyl chloride

1-(4-amino-phenyl)-piperidin-4-one