{3,5-dimethyl-1-[4-(4-trifluoromethyl-phenylethynyl)-benzyl]-1H-pyrazol-4-yl}-acetic acid

Base Information

Chemical Name:{3,5-dimethyl-1-[4-(4-trifluoromethyl-phenylethynyl)-benzyl]-1H-pyrazol-4-yl}-acetic acid
CAS No.:1322084-24-1
Molecular Formula:C₂₃H₁₉F₃N₂O₂
Molecular Weight:412.411
Hs Code.:

Synonyms:{3,5-dimethyl-1-[4-(4-trifluoromethyl-phenylethynyl)-benzyl]-1H-pyrazol-4-yl}-acetic acid

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Chemical Property of {3,5-dimethyl-1-[4-(4-trifluoromethyl-phenylethynyl)-benzyl]-1H-pyrazol-4-yl}-acetic acid

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Technology Process of {3,5-dimethyl-1-[4-(4-trifluoromethyl-phenylethynyl)-benzyl]-1H-pyrazol-4-yl}-acetic acid

There total 4 articles about {3,5-dimethyl-1-[4-(4-trifluoromethyl-phenylethynyl)-benzyl]-1H-pyrazol-4-yl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₂₁F₃N₂O₂

: 1322084-24-1
{3,5-dimethyl-1-[4-(4-trifluoromethyl-phenylethynyl)-benzyl]-1H-pyrazol-4-yl}-acetic acid

Guidance literature:: C₂₄H₂₁F₃N₂O₂; With water; sodium hydroxide; In 1,4-dioxane; for 1h;

With hydrogenchloride; In 1,4-dioxane; water;

Reference yield:

: 589-15-1
1-bromomethyl-4-bromobenzene

: 1322084-24-1
{3,5-dimethyl-1-[4-(4-trifluoromethyl-phenylethynyl)-benzyl]-1H-pyrazol-4-yl}-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 36 h / 20 - 50 °C

2: N-ethyl-N,N-diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 12 h / Reflux

3: sodium hydroxide; water / 1,4-dioxane / 1 h

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; acetonitrile; 2: Heck coupling;

Reference yield:

: 56699-23-1
(3,5-dimethyl-1H-pyrazol-4-yl)acetic acid methyl ester

: 1322084-24-1
{3,5-dimethyl-1-[4-(4-trifluoromethyl-phenylethynyl)-benzyl]-1H-pyrazol-4-yl}-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 36 h / 20 - 50 °C

2: N-ethyl-N,N-diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 12 h / Reflux

3: sodium hydroxide; water / 1,4-dioxane / 1 h

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; acetonitrile; 2: Heck coupling;