benzyl (2S,5'R)-2-benzyloxycarbonylamino-3-(1-methyl-2,4-dioxo-3-phenylhexahydropyrimidin-5-yl)propionate

Base Information

Chemical Name:benzyl (2S,5'R)-2-benzyloxycarbonylamino-3-(1-methyl-2,4-dioxo-3-phenylhexahydropyrimidin-5-yl)propionate
CAS No.:326891-02-5
Molecular Formula:C₂₉H₂₉N₃O₆
Molecular Weight:515.566
Hs Code.:

Synonyms:benzyl (2S,5'R)-2-benzyloxycarbonylamino-3-(1-methyl-2,4-dioxo-3-phenylhexahydropyrimidin-5-yl)propionate

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Chemical Property of benzyl (2S,5'R)-2-benzyloxycarbonylamino-3-(1-methyl-2,4-dioxo-3-phenylhexahydropyrimidin-5-yl)propionate

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Technology Process of benzyl (2S,5'R)-2-benzyloxycarbonylamino-3-(1-methyl-2,4-dioxo-3-phenylhexahydropyrimidin-5-yl)propionate

There total 6 articles about benzyl (2S,5'R)-2-benzyloxycarbonylamino-3-(1-methyl-2,4-dioxo-3-phenylhexahydropyrimidin-5-yl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.6%

: benzyl (2S)-N-benzyloxycarbonyl-4-[(1-methyl-3-phenylureido)methyl]pyroglutamate

: 326891-01-4
benzyl (2S,5'S)-2-benzyloxycarbonylamino-3-(1-methyl-2,4-dioxo-3-phenylhexahydropyrimidin-5-yl)propionate

: 326891-02-5
benzyl (2S,5'R)-2-benzyloxycarbonylamino-3-(1-methyl-2,4-dioxo-3-phenylhexahydropyrimidin-5-yl)propionate

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 134038-59-8
(S)-4-Formyl-5-oxo-pyrrolidine-1,2-dicarboxylic acid dibenzyl ester

: 326891-02-5
benzyl (2S,5'R)-2-benzyloxycarbonylamino-3-(1-methyl-2,4-dioxo-3-phenylhexahydropyrimidin-5-yl)propionate

Guidance literature:: Multi-step reaction with 4 steps

1: 0.25 h / 20 °C

2: sodium cyanoborohydride; aq. HCl / methanol / pH 3 - 4.6

4: sodium hydride / tetrahydrofuran

With hydrogenchloride; sodium hydride; sodium cyanoborohydride; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4039(00)01800-1

Reference yield:

: 103-71-9
phenyl isocyanate

: 326891-02-5
benzyl (2S,5'R)-2-benzyloxycarbonylamino-3-(1-methyl-2,4-dioxo-3-phenylhexahydropyrimidin-5-yl)propionate

Guidance literature:: Multi-step reaction with 2 steps

2: sodium hydride / tetrahydrofuran

With sodium hydride; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)01800-1