tert-butyl [trans-4-({3-[2-(methylsulfonyl)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}amino)cyclohexyl]carbamate

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Chemical Name:tert-butyl [trans-4-({3-[2-(methylsulfonyl)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}amino)cyclohexyl]carbamate
CAS No.:1330595-45-3
Molecular Formula:C₂₂H₂₉N₇O₄S
Molecular Weight:487.583
Hs Code.:

Synonyms:tert-butyl [trans-4-({3-[2-(methylsulfonyl)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}amino)cyclohexyl]carbamate

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Chemical Property of tert-butyl [trans-4-({3-[2-(methylsulfonyl)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}amino)cyclohexyl]carbamate

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Technology Process of tert-butyl [trans-4-({3-[2-(methylsulfonyl)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}amino)cyclohexyl]carbamate

There total 6 articles about tert-butyl [trans-4-({3-[2-(methylsulfonyl)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}amino)cyclohexyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1330595-44-2
tert-butyl [trans-4-({3-[2-(methylsulfanyl)pyrimidin-5-yl]imidazo-[1,2-b]pyridazin-6-yl}amino)cyclohexyl]carbamate

: 1330595-45-3
tert-butyl [trans-4-({3-[2-(methylsulfonyl)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}amino)cyclohexyl]carbamate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1330595-43-1
tert-butyl {trans-4-[(3-bromoimidazo[1,2-b]pyridazin-6-yl)amino]cyclohexyl}carbamate

: 1330595-45-3
tert-butyl [trans-4-({3-[2-(methylsulfonyl)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}amino)cyclohexyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 2.5 h / 90 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

With caesium carbonate; 3-chloro-benzenecarboperoxoic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 1330595-45-3
tert-butyl [trans-4-({3-[2-(methylsulfonyl)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}amino)cyclohexyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 30 h / 180 °C / microwave irradiation

2: dmap; triethylamine / tetrahydrofuran / 18 h / Reflux

3: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 2.5 h / 90 °C

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

With dmap; caesium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;