4-(2,4-dichloro-5-methoxyphenyl)-2-methylsulfanyl-7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

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Chemical Name:4-(2,4-dichloro-5-methoxyphenyl)-2-methylsulfanyl-7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
CAS No.:950662-12-1
Molecular Formula:C₂₁H₂₄Cl₂N₄O₂SSi
Molecular Weight:495.505
Hs Code.:

Synonyms:4-(2,4-dichloro-5-methoxyphenyl)-2-methylsulfanyl-7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

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Chemical Property of 4-(2,4-dichloro-5-methoxyphenyl)-2-methylsulfanyl-7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

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Technology Process of 4-(2,4-dichloro-5-methoxyphenyl)-2-methylsulfanyl-7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

There total 13 articles about 4-(2,4-dichloro-5-methoxyphenyl)-2-methylsulfanyl-7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 950661-71-9
4-chloro-2-methylsulfanyl-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid amide

: 950662-12-1
4-(2,4-dichloro-5-methoxyphenyl)-2-methylsulfanyl-7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate / N,N-dimethyl-formamide; water / 3 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; triethylamine; trifluoroacetic anhydride; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.08.050

Reference yield:

: 950661-70-8
4-chloro-2-methylsulfanyl-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid

: 950662-12-1
4-(2,4-dichloro-5-methoxyphenyl)-2-methylsulfanyl-7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0.17 h

1.2: 0.25 h / 20 °C

2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate / N,N-dimethyl-formamide; water / 3 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; oxalyl dichloride; sodium hydrogencarbonate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic anhydride; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.08.050

Reference yield:

: 189138-40-7
2,4-dichloro-5-iodo-1-methoxybenzene

: 950662-12-1
4-(2,4-dichloro-5-methoxyphenyl)-2-methylsulfanyl-7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C

2: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / water; N,N-dimethyl-formamide / 3.08 h / 80 °C

With n-butyllithium; sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide;