tert-butyl (2R,6S,13aS,14aR,16aS,Z)-5'-(3-fluorophenyl)-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-1',2',3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-1H-spiro[cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-2,3'-pyrano[2,3-c]quinoline]-6-ylcarbamate

Base Information

• Chemical Name: tert-butyl (2R,6S,13aS,14aR,16aS,Z)-5'-(3-fluorophenyl)-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-1',2',3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-1H-spiro[cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-2,3'-pyrano[2,3-c]quinoline]-6-ylcarbamate
• CAS No.: 1565770-99-1
• Molecular Formula: C₄₄H₅₂FN₅O₈S
• Molecular Weight: 829.99

Synonyms:tert-butyl (2R,6S,13aS,14aR,16aS,Z)-5'-(3-fluorophenyl)-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-1',2',3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-1H-spiro[cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-2,3'-pyrano[2,3-c]quinoline]-6-ylcarbamate

Chemical Property of tert-butyl (2R,6S,13aS,14aR,16aS,Z)-5'-(3-fluorophenyl)-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-1',2',3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-1H-spiro[cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-2,3'-pyrano[2,3-c]quinoline]-6-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (2R,6S,13aS,14aR,16aS,Z)-5'-(3-fluorophenyl)-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-1',2',3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-1H-spiro[cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-2,3'-pyrano[2,3-c]quinoline]-6-ylcarbamate

There total 19 articles about tert-butyl (2R,6S,13aS,14aR,16aS,Z)-5'-(3-fluorophenyl)-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-1',2',3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-1H-spiro[cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-2,3'-pyrano[2,3-c]quinoline]-6-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methylcyclopropane-1-sulfonamide (669008-26-8) + (2R,6S,12Z,13aS,14aR,16aS)-6-[(tert-butoxycarbonyl)amino]-5'-(3-fluorophenyl)-5,16-dioxo-1,1',2',6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrospiro[cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-2,3'-pyrano[2,3-c]quinoline]-14a(5H)-carboxylic acid (1565772-41-9) → tert-butyl (2R,6S,13aS,14aR,16aS,Z)-5'-(3-fluorophenyl)-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-1',2',3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-1H-spiro[cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-2,3'-pyrano[2,3-c]quinoline]-6-ylcarbamate (1565770-99-1)

Guidance literature:

(2R,6S,12Z,13aS,14aR,16aS)-6-[(tert-butoxycarbonyl)amino]-5'-(3-fluorophenyl)-5,16-dioxo-1,1',2',6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrospiro[cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-2,3'-pyrano[2,3-c]quinoline]-14a(5H)-carboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; for 2h; Reflux;

1-methylcyclopropane-1-sulfonamide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 - 50 ℃; for 58h;

Reference yield:

2-chloro-3-hydroxyquinoline-4-carboxylic acid (847547-91-5) → tert-butyl (2R,6S,13aS,14aR,16aS,Z)-5'-(3-fluorophenyl)-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-1',2',3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-1H-spiro[cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-2,3'-pyrano[2,3-c]quinoline]-6-ylcarbamate (1565770-99-1)

Guidance literature:

Multi-step reaction with 18 steps

1.1: methanol; toluene / Cooling with ice

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; ethanol; toluene / 6 h / 100 °C / Sealed tube; Inert atmosphere

3.1: diisobutylaluminium hydride / dichloromethane; toluene / 2.5 h / -78 - 20 °C

4.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1.5 h / 20 °C

5.1: tetrahydrofuran / 0 °C

6.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 20 °C

7.1: boron tribromide / dichloromethane / 1 h / 20 °C

8.1: pyrrolidine / methanol / 8 h / 100 °C / Molecular sieve; Sealed tube

9.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.75 h / 20 °C

10.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0 - 20 °C

10.2: 36 h / 20 °C

11.1: palladium 10% on activated carbon; hydrogen / ethyl acetate

12.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

13.1: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

14.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 1 h / 60 °C

15.1: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 20 °C

16.1: 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(iso-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methylene ruthenium(II) dichloride; p-benzoquinone / 1,2-dichloro-ethane / 3 h / 65 °C / Inert atmosphere

17.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 1 h / 60 °C

18.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / Reflux

18.2: 58 h / 20 - 50 °C

With pyrrolidine; hydrogenchloride; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(iso-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methylene ruthenium(II) dichloride; palladium 10% on activated carbon; N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; hydrogen; boron tribromide; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; p-benzoquinone; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

3-fluorophenylboronic acid (768-35-4) → tert-butyl (2R,6S,13aS,14aR,16aS,Z)-5'-(3-fluorophenyl)-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-1',2',3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-1H-spiro[cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-2,3'-pyrano[2,3-c]quinoline]-6-ylcarbamate (1565770-99-1)

Guidance literature:

Multi-step reaction with 17 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; ethanol; toluene / 6 h / 100 °C / Sealed tube; Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane; toluene / 2.5 h / -78 - 20 °C

3.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1.5 h / 20 °C

4.1: tetrahydrofuran / 0 °C

5.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 20 °C

6.1: boron tribromide / dichloromethane / 1 h / 20 °C

7.1: pyrrolidine / methanol / 8 h / 100 °C / Molecular sieve; Sealed tube

8.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.75 h / 20 °C

9.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0 - 20 °C

9.2: 36 h / 20 °C

10.1: palladium 10% on activated carbon; hydrogen / ethyl acetate

11.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

12.1: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

13.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 1 h / 60 °C

14.1: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 20 °C

15.1: 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(iso-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methylene ruthenium(II) dichloride; p-benzoquinone / 1,2-dichloro-ethane / 3 h / 65 °C / Inert atmosphere

16.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 1 h / 60 °C

17.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / Reflux

17.2: 58 h / 20 - 50 °C

With pyrrolidine; hydrogenchloride; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(iso-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methylene ruthenium(II) dichloride; palladium 10% on activated carbon; N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; hydrogen; boron tribromide; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; p-benzoquinone; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

upstream raw materials:

1-methylcyclopropane-1-sulfonamide

(2R,6S,12Z,13aS,14aR,16aS)-6-[(tert-butoxycarbonyl)amino]-5'-(3-fluorophenyl)-5,16-dioxo-1,1',2',6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrospiro[cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-2,3'-pyrano[2,3-c]quinoline]-14a(5H)-carboxylic acid

2-chloro-3-hydroxyquinoline-4-carboxylic acid

C₁₂H₁₀ClNO₃

Downstream raw materials:

C₃₉H₄₄FN₅O₆S*ClH

isobutyl (2R,6S,13aS,14aR,16aS,Z)-5'-(3-fluorophenyl)-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-1',2',3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-1H-spiro[cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-2,3'-pyrano[2,3-c]quinoline]-6-ylcarbamate

1-methylcyclopropyl (2R,6S,13aS,14aR,16aS,Z)-5'-(3-fluorophenyl)-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-1',2',3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-1H-spiro[cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-2,3'-pyrano[2,3-c]quinoline]-6-ylcarbamate

(2R,6S,13aS,14aR,16aS,Z)-6-(3-tert-butylureido)-5'-(3-fluorophenyl)-N-(1-methylcyclopropylsulfonyl)-5,16-dioxo-1',2',3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-1H-spiro[cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-2,3'-pyrano[2,3-c]quinoline]-14a-carboxamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1565770-99-1 tert-butyl (2R,6S,13aS,14aR,16aS,Z)-5'-(3-fluorophenyl)-14a-(1-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-1',2',3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-1H-spiro[cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-2,3'-pyrano[2,3-c]quinoline]-6-ylcarbamate

Send

Send

Metric Ton KG G Pound L ML

Send

Send