N-(N-benzyloxycarbonyl-β-alanyl)-β-alanine hydrazide

Base Information

• Chemical Name: N-(N-benzyloxycarbonyl-β-alanyl)-β-alanine hydrazide
• CAS No.: 111196-13-5
• Molecular Formula: C₁₄H₂₀N₄O₄
• Molecular Weight: 308.337
• Mol file: 111196-13-5.mol

Synonyms:N-(N-benzyloxycarbonyl-β-alanyl)-β-alanine hydrazide

Chemical Property of N-(N-benzyloxycarbonyl-β-alanyl)-β-alanine hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(N-benzyloxycarbonyl-β-alanyl)-β-alanine hydrazide

There total 2 articles about N-(N-benzyloxycarbonyl-β-alanyl)-β-alanine hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

N-(N-benzyloxycarbonyl-β-alanyl)-β-alanine ethyl ester (71710-18-4) → N-(N-benzyloxycarbonyl-β-alanyl)-β-alanine hydrazide (111196-13-5)

Guidance literature:

With hydrazine hydrate; In methanol; for 24h; Ambient temperature;

Reference yield:

3-(benzyloxycarbonylamino)propanoic acid (2304-94-1) → N-(N-benzyloxycarbonyl-β-alanyl)-β-alanine hydrazide (111196-13-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / N-ethylpiperidine, N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 1) -5 deg C; 2) 0 deg C, 2 h; 3) 12h, room temp.

2: 67 percent / 80percent hydrazine hydrate / methanol / 24 h / Ambient temperature

With 1-ethyl-piperidine; hydrazine hydrate; dicyclohexyl-carbodiimide; In methanol; dichloromethane;

Reference yield:

N-(N-benzyloxycarbonyl-β-alanyl)-β-alanine hydrazide (111196-13-5) → 3-Amino-N-{2-[(S)-1-(4-nitro-phenylcarbamoyl)-ethylcarbamoyl]-ethyl}-propionamide

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaNO₂, 20percent HCl

2: 36percent HBr, Zeolit G (OH form) / acetic acid / 1 h / Ambient temperature

With hydrogenchloride; Zeolit G (OH form); hydrogen bromide; sodium nitrite; In acetic acid;

upstream raw materials:

N-(N-benzyloxycarbonyl-β-alanyl)-β-alanine ethyl ester

3-(benzyloxycarbonylamino)propanoic acid

Downstream raw materials:

(2-{2-[(S)-1-(4-Nitro-phenylcarbamoyl)-ethylcarbamoyl]-ethylcarbamoyl}-ethyl)-carbamic acid benzyl ester

3-carboxypropionyl-β-alanyl-β-alanyl-alanine p-nitroanilide