N²-tert-butyloxycarbonyl-N¹-[8-(2,3,4-tri-O-benzyl-α-L-fucopyranosyloxy)-3,6-dioxaoctyl]-L-glutamic-α-amide

Base Information

• Chemical Name: N²-tert-butyloxycarbonyl-N¹-[8-(2,3,4-tri-O-benzyl-α-L-fucopyranosyloxy)-3,6-dioxaoctyl]-L-glutamic-α-amide
• CAS No.: 247907-51-3
• Molecular Formula: C₄₃H₅₈N₂O₁₂
• Molecular Weight: 794.94

Synonyms:N²-tert-butyloxycarbonyl-N¹-[8-(2,3,4-tri-O-benzyl-α-L-fucopyranosyloxy)-3,6-dioxaoctyl]-L-glutamic-α-amide

Chemical Property of N²-tert-butyloxycarbonyl-N¹-[8-(2,3,4-tri-O-benzyl-α-L-fucopyranosyloxy)-3,6-dioxaoctyl]-L-glutamic-α-amide

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-tert-butyloxycarbonyl-N¹-[8-(2,3,4-tri-O-benzyl-α-L-fucopyranosyloxy)-3,6-dioxaoctyl]-L-glutamic-α-amide

There total 2 articles about N²-tert-butyloxycarbonyl-N¹-[8-(2,3,4-tri-O-benzyl-α-L-fucopyranosyloxy)-3,6-dioxaoctyl]-L-glutamic-α-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

γ-benzyl N2-tert-butyloxycarbonyl-N1-[8-(2,3,4-tri-O-benzyl-α-L-fucopyranosyloxy)-3,6-dioxaoctyl]-L-glutamate-α-amide → N2-tert-butyloxycarbonyl-N1-[8-(2,3,4-tri-O-benzyl-α-L-fucopyranosyloxy)-3,6-dioxaoctyl]-L-glutamic-α-amide (247907-51-3)

Guidance literature:

With cyclohexa-1,4-diene; palladium on activated charcoal; In ethanol; at 20 ℃; for 1h;

DOI:10.1248/cpb.47.1237

Reference yield:

(S)-2-tert-Butoxycarbonylamino-pentanedioic acid 5-benzyl ester 1-(2,5-dioxo-pyrrolidin-1-yl) ester (32886-40-1) → N2-tert-butyloxycarbonyl-N1-[8-(2,3,4-tri-O-benzyl-α-L-fucopyranosyloxy)-3,6-dioxaoctyl]-L-glutamic-α-amide (247907-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine / CH₂Cl₂ / 1 h / 0 °C

2: 90 percent / 1,4-cyclohexadiene / 10 percent Pd/C / ethanol / 1 h / 20 °C

With 4-methyl-morpholine; cyclohexa-1,4-diene; palladium on activated charcoal; In ethanol; dichloromethane; 1: Condensation / 2: Hydrogenolysis;

DOI:10.1248/cpb.47.1237

Reference yield: 73.0%

N2-tert-butyloxycarbonyl-N1-[8-(2,3,4-tri-O-benzyl-α-L-fucopyranosyloxy)-3,6-dioxaoctyl]-L-glutamic-α-amide (247907-51-3) + (2S,4S,5R,6R)-4-Acetoxy-5-acetylamino-2-((2R,3R,4R,5S,6R)-3,5-diacetoxy-2-{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-6-benzoyloxymethyl-tetrahydro-pyran-4-yloxy)-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester; compound with toluene-4-sulfonic acid → N2-tert-butyloxycarbonyl-N5-[8-[O-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonate)-(2->3)-2,4-di-O-acetyl-6-O-benzoyl-β-D-galactopyranosyl]-3,6-dioxaoctyl]...

Guidance literature:

With 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 12h;

DOI:10.1248/cpb.47.1237

upstream raw materials:

(S)-2-tert-Butoxycarbonylamino-pentanedioic acid 5-benzyl ester 1-(2,5-dioxo-pyrrolidin-1-yl) ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 247907-51-3 N²-tert-butyloxycarbonyl-N¹-[8-(2,3,4-tri-O-benzyl-α-L-fucopyranosyloxy)-3,6-dioxaoctyl]-L-glutamic-α-amide

Send

Send

Metric Ton KG G Pound L ML

Send

Send