6-benzyl-3-chloro-5-(cyclobutyl-carbonyl)-2-methyl-6H-pyrazolo[1,5-c]pyrimidin-7-one

Base Information

Chemical Name:6-benzyl-3-chloro-5-(cyclobutyl-carbonyl)-2-methyl-6H-pyrazolo[1,5-c]pyrimidin-7-one
CAS No.:960292-57-3
Molecular Formula:C₁₉H₁₈ClN₃O₂
Molecular Weight:355.824
Hs Code.:

Synonyms:6-benzyl-3-chloro-5-(cyclobutyl-carbonyl)-2-methyl-6H-pyrazolo[1,5-c]pyrimidin-7-one

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Chemical Property of 6-benzyl-3-chloro-5-(cyclobutyl-carbonyl)-2-methyl-6H-pyrazolo[1,5-c]pyrimidin-7-one

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Technology Process of 6-benzyl-3-chloro-5-(cyclobutyl-carbonyl)-2-methyl-6H-pyrazolo[1,5-c]pyrimidin-7-one

There total 6 articles about 6-benzyl-3-chloro-5-(cyclobutyl-carbonyl)-2-methyl-6H-pyrazolo[1,5-c]pyrimidin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 960292-63-1
6-benzyl-3-chloro-5-((RS)-1-cyclobutyl-1-hydroxy-methyl)-2-methyl-6H-pyrazolo[1,5-c]pyrimidin-7-one

: 960292-57-3
6-benzyl-3-chloro-5-(cyclobutyl-carbonyl)-2-methyl-6H-pyrazolo[1,5-c]pyrimidin-7-one

Guidance literature:: With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; In dichloromethane; at 20 ℃; for 48h;

Reference yield:

: 960292-68-6
6-benzyl-3-chloro-2-methyl-7-oxo-6,7-dihydro-pyrazolo[1,5-c]pyrimidine-5-carbaldehyde

: 960292-57-3
6-benzyl-3-chloro-5-(cyclobutyl-carbonyl)-2-methyl-6H-pyrazolo[1,5-c]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: iodine; magnesium / diethyl ether / 1.5 h / Heating / reflux

1.2: 16 h / 20 °C

2.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 48 h / 20 °C

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; iodine; magnesium; In diethyl ether; dichloromethane;

Reference yield:

: 1004-36-0
2,6-dimethylpyrone

: 960292-57-3
6-benzyl-3-chloro-5-(cyclobutyl-carbonyl)-2-methyl-6H-pyrazolo[1,5-c]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide; ethanol; water / 6 h / 60 - 100 °C

2.1: sodium carbonate / water / 1 h / 100 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C

4.1: N-chloro-succinimide / tetrachloromethane / 5 h / Heating / reflux

5.1: selenium(IV) oxide / 1,4-dioxane / 5 h / Heating / reflux

6.1: iodine; magnesium / diethyl ether / 1.5 h / Heating / reflux

6.2: 16 h / 20 °C

7.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 48 h / 20 °C

With selenium(IV) oxide; sodium hydroxide; N-chloro-succinimide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; ethanol; [bis(acetoxy)iodo]benzene; water; iodine; sodium carbonate; potassium carbonate; magnesium; In 1,4-dioxane; tetrachloromethane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;