N-{(1R,2R)-2-[2-(9H-fluoren-9-yl)ethylamino]cyclohexyl}-2,2,2-trifluoroacetamide

Base Information

• Chemical Name: N-{(1R,2R)-2-[2-(9H-fluoren-9-yl)ethylamino]cyclohexyl}-2,2,2-trifluoroacetamide
• CAS No.: 1330776-32-3
• Molecular Formula: C₂₃H₂₅F₃N₂O
• Molecular Weight: 402.46

Synonyms:N-{(1R,2R)-2-[2-(9H-fluoren-9-yl)ethylamino]cyclohexyl}-2,2,2-trifluoroacetamide

Chemical Property of N-{(1R,2R)-2-[2-(9H-fluoren-9-yl)ethylamino]cyclohexyl}-2,2,2-trifluoroacetamide

Chemical Property:

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Technology Process of N-{(1R,2R)-2-[2-(9H-fluoren-9-yl)ethylamino]cyclohexyl}-2,2,2-trifluoroacetamide

There total 2 articles about N-{(1R,2R)-2-[2-(9H-fluoren-9-yl)ethylamino]cyclohexyl}-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.1%

N-[(1R,2R)-2-aminocyclohexyl]-2,2,2-trifluoroacetamide + 1-bromo-2-(9-fluorenyl)ethane (108012-21-1) → N-{(1R,2R)-2-[2-(9H-fluoren-9-yl)ethylamino]cyclohexyl}-2,2,2-trifluoroacetamide (1330776-32-3)

Guidance literature:

In 1,4-dioxane; at 120 ℃; for 168h;

DOI:10.1002/ejoc.201100550

Reference yield:

(1R,2R)-1,2-diaminocyclohexane (20439-47-8) → N-{(1R,2R)-2-[2-(9H-fluoren-9-yl)ethylamino]cyclohexyl}-2,2,2-trifluoroacetamide (1330776-32-3)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 0 °C

2: 1,4-dioxane / 168 h / 120 °C

In 1,4-dioxane; methanol;

DOI:10.1002/ejoc.201100550

Reference yield: 81.6%

N-{(1R,2R)-2-[2-(9H-fluoren-9-yl)ethylamino]cyclohexyl}-2,2,2-trifluoroacetamide (1330776-32-3) → C21H26N2 (1330776-33-4)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 1.5h; Reflux;

DOI:10.1002/ejoc.201100550

upstream raw materials:

1-bromo-2-(9-fluorenyl)ethane

(1R,2R)-1,2-diaminocyclohexane

Downstream raw materials:

C₂₁H₂₆N₂

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