methyl 4-(3-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)-2-fluorobenzoate

Base Information

Chemical Name:methyl 4-(3-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)-2-fluorobenzoate
CAS No.:1426531-20-5
Molecular Formula:C₃₀H₂₀F₄N₄O₄
Molecular Weight:576.507
Hs Code.:

Synonyms:methyl 4-(3-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)-2-fluorobenzoate

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Chemical Property of methyl 4-(3-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)-2-fluorobenzoate

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Technology Process of methyl 4-(3-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)-2-fluorobenzoate

There total 4 articles about methyl 4-(3-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)-2-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 603122-52-7
methyl 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: 1426531-08-9
7-bromo-N-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenyl)imidazo[1,2-a]pyridine-3-carboxamide

: 1426531-20-5
methyl 4-(3-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)-2-fluorobenzoate

Guidance literature:: methyl 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; 7-bromo-N-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenyl)imidazo[1,2-a]pyridine-3-carboxamide; With caesium carbonate; In 1,2-dimethoxyethane; water;

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; at 100 ℃; for 1h; Inert atmosphere;

Reference yield:

: 72235-53-1
3,4-difluorobenzylamine

: 1426531-20-5
methyl 4-(3-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)-2-fluorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine / tetrahydrofuran / 80 °C

2.1: thionyl chloride / 1.5 h / 100 °C

2.2: 1 h / 20 °C

3.1: caesium carbonate / 1,2-dimethoxyethane; water

3.2: 1 h / 100 °C / Inert atmosphere

With thionyl chloride; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; caesium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water;

Reference yield:

: 1305089-87-5
3-amino-N-(3,4-difluorobenzyl)-4-fluorobenzamide

: 1426531-20-5
methyl 4-(3-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)-2-fluorobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 1.5 h / 100 °C

1.2: 1 h / 20 °C

2.1: caesium carbonate / 1,2-dimethoxyethane; water

2.2: 1 h / 100 °C / Inert atmosphere

With thionyl chloride; caesium carbonate; In 1,2-dimethoxyethane; water;