(2-((4R,5R)-2,2-dimethyl-5-pentyl-1,3-dioxolan-4-yl)-4-methoxyphenyl)methanol

Base Information

Chemical Name:(2-((4R,5R)-2,2-dimethyl-5-pentyl-1,3-dioxolan-4-yl)-4-methoxyphenyl)methanol
CAS No.:1383781-62-1
Molecular Formula:C₁₈H₂₈O₄
Molecular Weight:308.418
Hs Code.:

Synonyms:(2-((4R,5R)-2,2-dimethyl-5-pentyl-1,3-dioxolan-4-yl)-4-methoxyphenyl)methanol

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Chemical Property of (2-((4R,5R)-2,2-dimethyl-5-pentyl-1,3-dioxolan-4-yl)-4-methoxyphenyl)methanol

Chemical Property:

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Technology Process of (2-((4R,5R)-2,2-dimethyl-5-pentyl-1,3-dioxolan-4-yl)-4-methoxyphenyl)methanol

There total 9 articles about (2-((4R,5R)-2,2-dimethyl-5-pentyl-1,3-dioxolan-4-yl)-4-methoxyphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1383781-60-9
(4R,5R)-4-(5-methoxy-2-methylphenyl)-2,2-dimethyl-5-pentyl-1,3-dioxolane

: 1383781-62-1
(2-((4R,5R)-2,2-dimethyl-5-pentyl-1,3-dioxolan-4-yl)-4-methoxyphenyl)methanol

Guidance literature:: With hydrogen; In ethanol; at 20 ℃; for 48h;
DOI:10.1016/j.tetlet.2012.05.012

Reference yield:

: 4741-63-3
6-methoxyphthalide

: 1383781-62-1
(2-((4R,5R)-2,2-dimethyl-5-pentyl-1,3-dioxolan-4-yl)-4-methoxyphenyl)methanol

Guidance literature:: Multi-step reaction with 9 steps

1.1: methanol; potassium carbonate / 3 h / Reflux

1.2: 5 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

3.2: -78 °C

4.1: tetrahydrofuran / 2 h / -10 °C

5.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 21 h / Inert atmosphere; Reflux

6.1: AD-mix β; methanesulfonamide / water; tert-butyl alcohol / 24 h / 0 °C

7.1: toluene-4-sulfonic acid / dichloromethane / 12 h / 20 °C

8.1: palladium 10% on activated carbon; hydrogen / ethanol / 5 h

9.1: hydrogen / ethanol / 48 h / 20 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; methanol; lithium aluminium tetrahydride; oxalyl dichloride; methanesulfonamide; AD-mix β; palladium 10% on activated carbon; hydrogen; potassium carbonate; toluene-4-sulfonic acid; dimethyl sulfoxide; In tetrahydrofuran; ethanol; dichloromethane; water; tert-butyl alcohol; 4.1: Wittig reaction;
DOI:10.1016/j.tetlet.2012.05.012

Reference yield:

: 1383781-52-9
1-(benzyloxymethyl)-4-methoxy-2-vinylbenzene

: 1383781-62-1
(2-((4R,5R)-2,2-dimethyl-5-pentyl-1,3-dioxolan-4-yl)-4-methoxyphenyl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 21 h / Inert atmosphere; Reflux

2: AD-mix β; methanesulfonamide / water; tert-butyl alcohol / 24 h / 0 °C

3: toluene-4-sulfonic acid / dichloromethane / 12 h / 20 °C

4: palladium 10% on activated carbon; hydrogen / ethanol / 5 h

5: hydrogen / ethanol / 48 h / 20 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; methanesulfonamide; AD-mix β; palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; In ethanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2012.05.012