Technology Process of (R)-2-[1-(4-bromophenyl)-1-phenylpropyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
There total 1 articles about (R)-2-[1-(4-bromophenyl)-1-phenylpropyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-N,N-diisopropylcarbamic acid 1-phenylpropyl ester;
With
sec.-butyllithium;
In
diethyl ether; hexane; cyclohexane;
at -75 - -70 ℃;
for 0.333333h;
p-bromophenylboronic acid pinacol ester;
In
diethyl ether; hexane; cyclohexane;
at -70 ℃;
for 1.16667h;
optical yield given as %ee;
Further stages;
DOI:10.1002/anie.201001371
- Guidance literature:
-
With
ethylenediaminetetraacetic acid; dihydrogen peroxide; sodium hydroxide;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
optical yield given as %ee;
Inert atmosphere;
DOI:10.1002/anie.201001371