6-Methyl-2-[methyl-(2-oxo-2-phenyl-ethyl)-amino]-chromen-4-one

Base Information

• Chemical Name: 6-Methyl-2-[methyl-(2-oxo-2-phenyl-ethyl)-amino]-chromen-4-one
• CAS No.: 199474-00-5
• Molecular Formula: C₁₉H₁₇NO₃
• Molecular Weight: 307.349
• Mol file: 199474-00-5.mol

Synonyms:6-Methyl-2-[methyl-(2-oxo-2-phenyl-ethyl)-amino]-chromen-4-one

Chemical Property of 6-Methyl-2-[methyl-(2-oxo-2-phenyl-ethyl)-amino]-chromen-4-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 6-Methyl-2-[methyl-(2-oxo-2-phenyl-ethyl)-amino]-chromen-4-one

There total 1 articles about 6-Methyl-2-[methyl-(2-oxo-2-phenyl-ethyl)-amino]-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-(methylamino)-1-phenylethanone hydrochloride (23826-47-3) + 2-Chloro-6-methyl-chromen-4-one → 6-Methyl-2-[methyl-(2-oxo-2-phenyl-ethyl)-amino]-chromen-4-one (199474-00-5)

Guidance literature:

With triethylamine; In ethanol; at 20 ℃; for 96h;

DOI:10.1016/S0040-4020(97)10077-1

Reference yield: 65.0%

6-Methyl-2-[methyl-(2-oxo-2-phenyl-ethyl)-amino]-chromen-4-one (199474-00-5) → 1,6-Dimethyl-3-phenyl-1H-chromeno[2,3-b]pyrrol-4-one (199474-12-9)

Guidance literature:

With pyrrolidine; In acetic acid; for 48h; Heating;

DOI:10.1016/S0040-4020(97)10077-1

Reference yield:

6-Methyl-2-[methyl-(2-oxo-2-phenyl-ethyl)-amino]-chromen-4-one (199474-00-5) → 1,6-Dimethyl-2-nitro-3-phenyl-1H-chromeno[2,3-b]pyrrol-4-one

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / pyrrolidine / acetic acid / 48 h / Heating

2: 58 percent / HNO₃, Ac₂O / 2 h / -5 - 0 °C

With pyrrolidine; nitric acid; acetic anhydride; In acetic acid;

DOI:10.1016/S0040-4020(97)10077-1

upstream raw materials:

2-(methylamino)-1-phenylethanone hydrochloride

Downstream raw materials:

1,6-Dimethyl-3-phenyl-1H-chromeno[2,3-b]pyrrol-4-one