5-(2-aminoethyl)-3-(4-methoxyphenyl)-7-(toluene-4-sulfonyl)-2,3-dihydro-1H,7H-pyrrolo[3,2-f]indole-4,8-dione

Base Information

• Chemical Name: 5-(2-aminoethyl)-3-(4-methoxyphenyl)-7-(toluene-4-sulfonyl)-2,3-dihydro-1H,7H-pyrrolo[3,2-f]indole-4,8-dione
• CAS No.: 1132806-28-0
• Molecular Formula: C₂₆H₂₅N₃O₅S
• Molecular Weight: 491.568

Synonyms:5-(2-aminoethyl)-3-(4-methoxyphenyl)-7-(toluene-4-sulfonyl)-2,3-dihydro-1H,7H-pyrrolo[3,2-f]indole-4,8-dione

Chemical Property of 5-(2-aminoethyl)-3-(4-methoxyphenyl)-7-(toluene-4-sulfonyl)-2,3-dihydro-1H,7H-pyrrolo[3,2-f]indole-4,8-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 5-(2-aminoethyl)-3-(4-methoxyphenyl)-7-(toluene-4-sulfonyl)-2,3-dihydro-1H,7H-pyrrolo[3,2-f]indole-4,8-dione

There total 2 articles about 5-(2-aminoethyl)-3-(4-methoxyphenyl)-7-(toluene-4-sulfonyl)-2,3-dihydro-1H,7H-pyrrolo[3,2-f]indole-4,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-[2-hydroxy-2-(4-methoxyphenyl)ethylamino]-4,7-dioxo-3-(2-tert-butyloxycarbonylaminoethyl)-1-(toluene-4-sulfonyl)indole (1132806-26-8) → 5-(2-aminoethyl)-3-(4-methoxyphenyl)-7-(toluene-4-sulfonyl)-2,3-dihydro-1H,7H-pyrrolo[3,2-f]indole-4,8-dione (1132806-28-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2008.12.078

Reference yield:

tert-butyl (2-{1-[(4-methylphenyl)sulfonyl]-4,7-dioxo-4,7-dihydro-1H-indol-3-yl}ethyl)carbamate (220034-57-1) → 5-(2-aminoethyl)-3-(4-methoxyphenyl)-7-(toluene-4-sulfonyl)-2,3-dihydro-1H,7H-pyrrolo[3,2-f]indole-4,8-dione (1132806-28-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 2 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With trifluoroacetic acid; In ethanol; dichloromethane; 1: |Michael Addition;

DOI:10.1016/j.bmcl.2012.11.036

Reference yield:

5-(2-aminoethyl)-3-(4-methoxyphenyl)-7-(toluene-4-sulfonyl)-2,3-dihydro-1H,7H-pyrrolo[3,2-f]indole-4,8-dione (1132806-28-0) → 3-(2-aminoethyl)-5-(4-methoxyphenyl)-1-(toluene-4-sulfonyl)-1H,7H-pyrrolo[3,2-f]indole-4,8-dione (1132806-29-1)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃;

DOI:10.1016/j.tetlet.2008.12.078

upstream raw materials:

6-[2-hydroxy-2-(4-methoxyphenyl)ethylamino]-4,7-dioxo-3-(2-tert-butyloxycarbonylaminoethyl)-1-(toluene-4-sulfonyl)indole

tert-butyl (2-{1-[(4-methylphenyl)sulfonyl]-4,7-dioxo-4,7-dihydro-1H-indol-3-yl}ethyl)carbamate

Downstream raw materials:

3-(2-aminoethyl)-5-(4-methoxyphenyl)-1-(toluene-4-sulfonyl)-1H,7H-pyrrolo[3,2-f]indole-4,8-dione

9-(4-methoxyphenyl)-2,3,5,7-tetrahydro-1,5,7-triazacyclopenta[e]acenaphthylen-6-one

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