2-((S)-6-((R)-4-(2,6-dimethyl-4-(2-methyl-2H-tetrazol-5-yl)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

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Chemical Name:2-((S)-6-((R)-4-(2,6-dimethyl-4-(2-methyl-2H-tetrazol-5-yl)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid
CAS No.:1458657-61-8
Molecular Formula:C₂₉H₂₇FN₄O₄
Molecular Weight:514.556
Hs Code.:

Synonyms:2-((S)-6-((R)-4-(2,6-dimethyl-4-(2-methyl-2H-tetrazol-5-yl)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

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Chemical Property of 2-((S)-6-((R)-4-(2,6-dimethyl-4-(2-methyl-2H-tetrazol-5-yl)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

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Technology Process of 2-((S)-6-((R)-4-(2,6-dimethyl-4-(2-methyl-2H-tetrazol-5-yl)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

There total 14 articles about 2-((S)-6-((R)-4-(2,6-dimethyl-4-(2-methyl-2H-tetrazol-5-yl)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1458655-63-4
5-(4-bromo-3,5-dimethyl-phenyl)-2-methyl-2H-tetrazole

: {(S)-6-[(R)-7-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-indan-1-yloxy]-2,3-dihydrobenzofuran-3-yl}acetic acid

: 1458657-61-8
2-((S)-6-((R)-4-(2,6-dimethyl-4-(2-methyl-2H-tetrazol-5-yl)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

Guidance literature:: With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; water; at 100 ℃; Inert atmosphere;

Reference yield:

: 1458652-57-7
(S)-4-bromo-7-fluoro -2,3-dihydro-1H-inden-1-ol

: 1458657-61-8
2-((S)-6-((R)-4-(2,6-dimethyl-4-(2-methyl-2H-tetrazol-5-yl)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: tributylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.83 h / -10 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

1.3: 80 °C

2.1: [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; hydrogen; (R)-1-[(S)-(2-di(4-methoxy-3,5-dimethylphenyl)phosphino)ferrocenyl]ethyldi-tert-butylphosphine; triethylamine / methanol / 20 h / 50 °C / 18751.9 Torr / Inert atmosphere

3.1: potassium acetate; palladium diacetate; catacxium A / 2-methyltetrahydrofuran / 80 °C / Inert atmosphere

4.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium phosphate / 1,4-dioxane; water / 100 °C / Inert atmosphere

With potassium phosphate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; (R)-1-[(S)-(2-di(4-methoxy-3,5-dimethylphenyl)phosphino)ferrocenyl]ethyldi-tert-butylphosphine; tributylphosphine; di-isopropyl azodicarboxylate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); hydrogen; potassium acetate; palladium diacetate; triethylamine; catacxium A; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; methanol; water; 1.1: |Mitsunobu Displacement;

Reference yield:

: 1003048-72-3
4-bromo-7-fluoro-2,3-dihydro-1H-inden-1-one

: 1458657-61-8
2-((S)-6-((R)-4-(2,6-dimethyl-4-(2-methyl-2H-tetrazol-5-yl)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: (1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine-ruthenium(mesitylene); formic acid; triethylamine / toluene / 2.5 h / 40 °C / Inert atmosphere

1.2: 0.5 h / Inert atmosphere

2.1: di-tert-butyl-diazodicarboxylate; tributylphosphine / tetrahydrofuran / 1.08 h / -10 °C

3.1: sodium hydroxide; water / methanol / 0.83 h / 40 °C

4.1: [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; hydrogen; (R)-1-[(S)-(2-di(4-methoxy-3,5-dimethylphenyl)phosphino)ferrocenyl]ethyldi-tert-butylphosphine; triethylamine / methanol / 20 h / 50 °C / 18751.9 Torr / Inert atmosphere

5.1: potassium acetate; palladium diacetate; catacxium A / 2-methyltetrahydrofuran / 80 °C / Inert atmosphere

6.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium phosphate / 1,4-dioxane; water / 100 °C / Inert atmosphere

With potassium phosphate; (1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine-ruthenium(mesitylene); formic acid; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; (R)-1-[(S)-(2-di(4-methoxy-3,5-dimethylphenyl)phosphino)ferrocenyl]ethyldi-tert-butylphosphine; tributylphosphine; di-tert-butyl-diazodicarboxylate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); water; hydrogen; potassium acetate; palladium diacetate; triethylamine; sodium hydroxide; catacxium A; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; methanol; water; toluene; 2.1: |Mitsunobu Displacement;