(2R,3S)-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)-4-hydroxybutyronitrile

Base Information

Chemical Name:(2R,3S)-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)-4-hydroxybutyronitrile
CAS No.:276684-43-6
Molecular Formula:C₂₀H₂₂N₂O₄
Molecular Weight:354.406
Hs Code.:

Synonyms:(2R,3S)-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)-4-hydroxybutyronitrile

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Chemical Property of (2R,3S)-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)-4-hydroxybutyronitrile

Chemical Property:

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Technology Process of (2R,3S)-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)-4-hydroxybutyronitrile

There total 5 articles about (2R,3S)-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)-4-hydroxybutyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 276684-42-5
(2R,3S)-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)-4-(tert-butyldimethylsilyloxy)butyronitrile

: 276684-43-6
(2R,3S)-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)-4-hydroxybutyronitrile

Guidance literature:: With acetic acid; at 20 ℃; for 96h;
DOI:10.1016/S0957-4166(00)00022-7

Reference yield:

: 98944-53-7
(S)-2-O-benzyl-3-O-(tert-butyldimethylsilyl)-D-glyceraldehyde

: 276684-43-6
(2R,3S)-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)-4-hydroxybutyronitrile

Guidance literature:: Multi-step reaction with 4 steps

1: MgSO₄ / tetrahydrofuran / 3 h

2: 64 percent / CH₂Cl₂ / 12 h / 20 °C

3: 98 percent / K₂CO₃ / tetrahydrofuran / 5 h / 20 °C

4: 99 percent / aq. AcOH / 96 h / 20 °C

With magnesium sulfate; potassium carbonate; acetic acid; In tetrahydrofuran; dichloromethane; 1: Condensation / 2: Addition / 3: Acylation / 4: desilylation;
DOI:10.1016/S0957-4166(00)00022-7

Reference yield:

: 100-46-9
benzylamine

: 276684-43-6
(2R,3S)-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)-4-hydroxybutyronitrile

Guidance literature:: Multi-step reaction with 4 steps

1: MgSO₄ / tetrahydrofuran / 3 h

2: 64 percent / CH₂Cl₂ / 12 h / 20 °C

3: 98 percent / K₂CO₃ / tetrahydrofuran / 5 h / 20 °C

4: 99 percent / aq. AcOH / 96 h / 20 °C

With magnesium sulfate; potassium carbonate; acetic acid; In tetrahydrofuran; dichloromethane; 1: Condensation / 2: Addition / 3: Acylation / 4: desilylation;
DOI:10.1016/S0957-4166(00)00022-7