N-(2-bromo-benzyl)-N-(2-phenylsulfanyl-vinyl)-propionamide

Base Information

• Chemical Name: N-(2-bromo-benzyl)-N-(2-phenylsulfanyl-vinyl)-propionamide
• CAS No.: 300661-43-2
• Molecular Formula: C₁₈H₁₈BrNOS
• Molecular Weight: 376.317
• Mol file: 300661-43-2.mol

Synonyms:N-(2-bromo-benzyl)-N-(2-phenylsulfanyl-vinyl)-propionamide

Chemical Property of N-(2-bromo-benzyl)-N-(2-phenylsulfanyl-vinyl)-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-bromo-benzyl)-N-(2-phenylsulfanyl-vinyl)-propionamide

There total 3 articles about N-(2-bromo-benzyl)-N-(2-phenylsulfanyl-vinyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

trifluoroacetic anhydride (407-25-0) + N-(2-benzenesulfinyl-ethyl)-N-(2-bromo-benzyl)-propionamide (300661-41-0) → N-(2-bromo-benzyl)-N-(2-phenylsulfanyl-vinyl)-propionamide (300661-44-3) + N-(2-bromo-benzyl)-N-(2-phenylsulfanyl-vinyl)-propionamide (300661-43-2)

Guidance literature:

trifluoroacetic anhydride; N-(2-benzenesulfinyl-ethyl)-N-(2-bromo-benzyl)-propionamide; In dichloromethane; at 20 ℃;

In toluene; Further stages.; Heating;

DOI:10.1039/b003790g

Reference yield:

N-(2-bromobenzyl)-2-(phenylthio)ethanamine → N-(2-bromo-benzyl)-N-(2-phenylsulfanyl-vinyl)-propionamide (300661-43-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 90 percent / Et₃N / CH₂Cl₂ / 20 °C

2.1: 93 percent / MCPBA / CH₂Cl₂ / 0 °C

3.1: CH₂Cl₂ / 20 °C

3.2: 46 percent / toluene / Heating

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; 1.1: Acylation / 2.1: Oxidation / 3.1: Substitution / 3.2: Elimination;

DOI:10.1039/b003790g

Reference yield:

N-(2-bromo-benzyl)-N-(2-phenylsulfanyl-ethyl)-propionamide (300661-40-9) → N-(2-bromo-benzyl)-N-(2-phenylsulfanyl-vinyl)-propionamide (300661-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 93 percent / MCPBA / CH₂Cl₂ / 0 °C

2.1: CH₂Cl₂ / 20 °C

2.2: 46 percent / toluene / Heating

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; 1.1: Oxidation / 2.1: Substitution / 2.2: Elimination;

DOI:10.1039/b003790g

upstream raw materials:

trifluoroacetic anhydride

N-(2-benzenesulfinyl-ethyl)-N-(2-bromo-benzyl)-propionamide

N-(2-bromo-benzyl)-N-(2-phenylsulfanyl-ethyl)-propionamide

Downstream raw materials:

1-(1H-isoquinolin-2-yl)-propan-1-one