(E)-ethyl 2-(3-(6-hydroxynaphthalen-2-yl)acrylamido)cyclohex-1-enecarboxylate

Base Information

Chemical Name:(E)-ethyl 2-(3-(6-hydroxynaphthalen-2-yl)acrylamido)cyclohex-1-enecarboxylate
CAS No.:1616119-48-2
Molecular Formula:C₂₂H₂₃NO₄
Molecular Weight:365.429
Hs Code.:

Synonyms:(E)-ethyl 2-(3-(6-hydroxynaphthalen-2-yl)acrylamido)cyclohex-1-enecarboxylate

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Chemical Property of (E)-ethyl 2-(3-(6-hydroxynaphthalen-2-yl)acrylamido)cyclohex-1-enecarboxylate

Chemical Property:

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Technology Process of (E)-ethyl 2-(3-(6-hydroxynaphthalen-2-yl)acrylamido)cyclohex-1-enecarboxylate

There total 7 articles about (E)-ethyl 2-(3-(6-hydroxynaphthalen-2-yl)acrylamido)cyclohex-1-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1616119-46-0
(E)-ethyl 2-(3-(6-((tert-butyldimethylsilyl)oxy)naphthalen-2-yl)acrylamido)cyclohex-1-enecarboxylate

: 1616119-48-2
(E)-ethyl 2-(3-(6-hydroxynaphthalen-2-yl)acrylamido)cyclohex-1-enecarboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 10 - 20 ℃; for 1h;
DOI:10.1016/j.bmc.2014.05.011

Reference yield:

: 253266-43-2
6-((tert-butyldimethylsilyl)oxy)-2-naphthaldehyde

: 1616119-48-2
(E)-ethyl 2-(3-(6-hydroxynaphthalen-2-yl)acrylamido)cyclohex-1-enecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; 18-crown-6 ether / dichloromethane / 24 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 10 - 20 °C

With 18-crown-6 ether; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; dichloromethane; 1: |Wittig Olefination;
DOI:10.1016/j.bmc.2014.05.011

Reference yield:

: 1616119-20-0
ethyl 2-(2-bromoacetamido)cyclohex-1-enecarboxylate

: 1616119-48-2
(E)-ethyl 2-(3-(6-hydroxynaphthalen-2-yl)acrylamido)cyclohex-1-enecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: benzene / 3 h / Reflux

2: potassium carbonate; 18-crown-6 ether / dichloromethane / 24 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 10 - 20 °C

With 18-crown-6 ether; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; dichloromethane; benzene; 2: |Wittig Olefination;
DOI:10.1016/j.bmc.2014.05.011