tert-butyl 2-(7-acetyl-9-(4-(diethoxyphosphoryloxy)phenyl)-3-oxo-1Hpyrrolo[3,4-b]indolizin-2(3H)-yl)ethyl carbamate

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Chemical Name:tert-butyl 2-(7-acetyl-9-(4-(diethoxyphosphoryloxy)phenyl)-3-oxo-1Hpyrrolo[3,4-b]indolizin-2(3H)-yl)ethyl carbamate
CAS No.:1384108-32-0
Molecular Formula:C₂₉H₃₆N₃O₈P
Molecular Weight:585.594
Hs Code.:

Synonyms:tert-butyl 2-(7-acetyl-9-(4-(diethoxyphosphoryloxy)phenyl)-3-oxo-1Hpyrrolo[3,4-b]indolizin-2(3H)-yl)ethyl carbamate

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Chemical Property of tert-butyl 2-(7-acetyl-9-(4-(diethoxyphosphoryloxy)phenyl)-3-oxo-1Hpyrrolo[3,4-b]indolizin-2(3H)-yl)ethyl carbamate

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Technology Process of tert-butyl 2-(7-acetyl-9-(4-(diethoxyphosphoryloxy)phenyl)-3-oxo-1Hpyrrolo[3,4-b]indolizin-2(3H)-yl)ethyl carbamate

There total 7 articles about tert-butyl 2-(7-acetyl-9-(4-(diethoxyphosphoryloxy)phenyl)-3-oxo-1Hpyrrolo[3,4-b]indolizin-2(3H)-yl)ethyl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.8%

: 1292324-02-7
tert-butyl 2-(7-acetyl-9-(4-hydroxyphenyl)-3-oxo-1H-pyrrolo[3,4-β]indolizin-2(3H)-yl)ethylcarbamate

: 122-52-1
triethyl phosphite

: 1384108-32-0
tert-butyl 2-(7-acetyl-9-(4-(diethoxyphosphoryloxy)phenyl)-3-oxo-1Hpyrrolo[3,4-b]indolizin-2(3H)-yl)ethyl carbamate

Guidance literature:: With dmap; iodine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1039/c2cc31377d

Reference yield:

: 1292324-01-6
tert-butyl 2-(7-acetyl-9-(4-(tert-butyldimethylsilyloxy)phenyl)-3-oxo-1H-pyrrolo[3,4-β]indolizin-2(3H)-yl)ethylcarbamate

: 1384108-32-0
tert-butyl 2-(7-acetyl-9-(4-(diethoxyphosphoryloxy)phenyl)-3-oxo-1Hpyrrolo[3,4-b]indolizin-2(3H)-yl)ethyl carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; hydrogen fluoride / tetrahydrofuran

2: dmap; iodine / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; hydrogen fluoride; iodine; In tetrahydrofuran; dichloromethane; 2: Arbuzov reaction;
DOI:10.1039/c2cc31377d

Reference yield:

: C₁₅H₂₂O₂Si

: 1384108-32-0
tert-butyl 2-(7-acetyl-9-(4-(diethoxyphosphoryloxy)phenyl)-3-oxo-1Hpyrrolo[3,4-b]indolizin-2(3H)-yl)ethyl carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid; sodium sulfate / dichloromethane / 20 °C

2: sodium tetrahydroborate / methanol / 0 °C

3: triethylamine / dichloromethane / -78 °C

4: dichloromethane / 60 °C

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene

6: pyridine; hydrogen fluoride / tetrahydrofuran

7: dmap; iodine / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; sodium tetrahydroborate; hydrogen fluoride; iodine; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium sulfate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; toluene; 7: Arbuzov reaction;
DOI:10.1039/c2cc31377d