7-(2-hydroxy-3-(4-p-tolyl-1H-1,2,3-triazol-1-yl)propoxy)spiro[chroman-2,1'-cyclohexan]-4-one

Base Information

Chemical Name:7-(2-hydroxy-3-(4-p-tolyl-1H-1,2,3-triazol-1-yl)propoxy)spiro[chroman-2,1'-cyclohexan]-4-one
CAS No.:1300594-09-5
Molecular Formula:C₂₆H₂₉N₃O₄
Molecular Weight:447.534
Hs Code.:

Synonyms:7-(2-hydroxy-3-(4-p-tolyl-1H-1,2,3-triazol-1-yl)propoxy)spiro[chroman-2,1'-cyclohexan]-4-one

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Chemical Property of 7-(2-hydroxy-3-(4-p-tolyl-1H-1,2,3-triazol-1-yl)propoxy)spiro[chroman-2,1'-cyclohexan]-4-one

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Technology Process of 7-(2-hydroxy-3-(4-p-tolyl-1H-1,2,3-triazol-1-yl)propoxy)spiro[chroman-2,1'-cyclohexan]-4-one

There total 5 articles about 7-(2-hydroxy-3-(4-p-tolyl-1H-1,2,3-triazol-1-yl)propoxy)spiro[chroman-2,1'-cyclohexan]-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1300594-05-1
7-(3-azido-2-hydroxypropoxy)spiro[chroman-2,1'-cyclohexan]-4-one

: 766-97-2
4-n-methylphenylacetylene

: 1300594-09-5
7-(2-hydroxy-3-(4-p-tolyl-1H-1,2,3-triazol-1-yl)propoxy)spiro[chroman-2,1'-cyclohexan]-4-one

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 60 ℃; for 12h;
DOI:10.1016/j.tetlet.2011.02.099

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1300594-09-5
7-(2-hydroxy-3-(4-p-tolyl-1H-1,2,3-triazol-1-yl)propoxy)spiro[chroman-2,1'-cyclohexan]-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: pyrrolidine / acetonitrile / 24 h / 50 °C

2: potassium carbonate / acetone / 12 h / Reflux

3: sodium azide; ammonium chloride / methanol / 5 h / Reflux

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 12 h / 60 °C

With pyrrolidine; sodium azide; copper(ll) sulfate pentahydrate; potassium carbonate; ammonium chloride; sodium L-ascorbate; In methanol; water; acetone; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2011.02.099

Reference yield:

: 1300594-03-9
7-(oxiran-2-ylmethoxy)spiro[chroman-2,1'-cyclohexan]-4-one

: 1300594-09-5
7-(2-hydroxy-3-(4-p-tolyl-1H-1,2,3-triazol-1-yl)propoxy)spiro[chroman-2,1'-cyclohexan]-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide; ammonium chloride / methanol / 5 h / Reflux

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 12 h / 60 °C

With sodium azide; copper(ll) sulfate pentahydrate; ammonium chloride; sodium L-ascorbate; In methanol; water; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2011.02.099