(+/-)-methyl 6-(3-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)butylamino)nicotinate

Base Information

Chemical Name:(+/-)-methyl 6-(3-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)butylamino)nicotinate
CAS No.:1393126-69-6
Molecular Formula:C₂₂H₂₃F₃N₄O₂
Molecular Weight:432.445
Hs Code.:

Synonyms:(+/-)-methyl 6-(3-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)butylamino)nicotinate

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Chemical Property of (+/-)-methyl 6-(3-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)butylamino)nicotinate

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Technology Process of (+/-)-methyl 6-(3-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)butylamino)nicotinate

There total 2 articles about (+/-)-methyl 6-(3-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)butylamino)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73781-91-6
6-Chloronicotinic acid methyl ester

: 1393125-35-3
(+/-)-3-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)butan-1-amine

: 1393126-69-6
(+/-)-methyl 6-(3-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)butylamino)nicotinate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 130 ℃; for 15h; Microwave irradiation;

Reference yield:

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 1393126-69-6
(+/-)-methyl 6-(3-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)butylamino)nicotinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 0 - 80 °C

2.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 100 °C

2.2: 0.08 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 15 h / 130 °C / Microwave irradiation

With sodium tetrahydroborate; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil; 2.1: Grignard Reaction;

Reference yield: 87.0%

: 1393126-69-6
(+/-)-methyl 6-(3-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)butylamino)nicotinate

: 1393126-68-5
(+/-)-6-(3-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)butylamino)nicotinic acid

Guidance literature:: (+/-)-methyl 6-(3-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)butylamino)nicotinate; With water; lithium hydroxide; In tetrahydrofuran; at 50 ℃;

With hydrogenchloride; In tetrahydrofuran; water;