rac-2-(4-chloroethynyl-2,6-dimethylphenyl)-4-(pyridin-2-ylmethyl)cyclopentane-1,3-dione

Base Information

Chemical Name:rac-2-(4-chloroethynyl-2,6-dimethylphenyl)-4-(pyridin-2-ylmethyl)cyclopentane-1,3-dione
CAS No.:1439560-27-6
Molecular Formula:C₂₁H₁₈ClNO₂
Molecular Weight:351.832
Hs Code.:

Synonyms:rac-2-(4-chloroethynyl-2,6-dimethylphenyl)-4-(pyridin-2-ylmethyl)cyclopentane-1,3-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-2-(4-chloroethynyl-2,6-dimethylphenyl)-4-(pyridin-2-ylmethyl)cyclopentane-1,3-dione

Chemical Property:

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Technology Process of rac-2-(4-chloroethynyl-2,6-dimethylphenyl)-4-(pyridin-2-ylmethyl)cyclopentane-1,3-dione

There total 9 articles about rac-2-(4-chloroethynyl-2,6-dimethylphenyl)-4-(pyridin-2-ylmethyl)cyclopentane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1439557-82-0
rac-2-(4-chloroethynyl-2,6-dimethylphenyl)-3-methoxy-5-(pyridin-2-ylmethyl)cyclopent-2-enone

: 1439560-27-6
rac-2-(4-chloroethynyl-2,6-dimethylphenyl)-4-(pyridin-2-ylmethyl)cyclopentane-1,3-dione

Guidance literature:: With hydrogenchloride; In water; acetone; at 60 ℃; for 2h;

Reference yield:

: 2-(4-bromo-2,6-dimethylphenyl)cyclopentane-1,3-dione

: 1439560-27-6
rac-2-(4-chloroethynyl-2,6-dimethylphenyl)-4-(pyridin-2-ylmethyl)cyclopentane-1,3-dione

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / acetone / 16 h / 25 - 30 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.67 h / -75 °C / Inert atmosphere

2.2: 4.33 h / -75 - 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 0 - 20 °C

4.1: potassium carbonate / methanol / 25 - 30 °C

5.1: acetic acid; zinc / 25 - 30 °C

6.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride; copper(l) iodide / N,N-dimethyl-formamide / 1 h / 110 °C / Inert atmosphere; Microwave irradiation

7.1: N-chloro-succinimide; silver(I) acetate / acetone / Reflux

8.1: hydrogenchloride / acetone; water / 2 h / 60 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-chloro-succinimide; copper(l) iodide; silver(I) acetate; potassium carbonate; acetic acid; triethylamine; cesium fluoride; lithium hexamethyldisilazane; zinc; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1439557-55-7
rac-2-(4-bromo-2,6-dimethylphenyl)-3-methoxy-5-(pyridin-2-ylmethyl)cyclopent-2-enone

: 1439560-27-6
rac-2-(4-chloroethynyl-2,6-dimethylphenyl)-4-(pyridin-2-ylmethyl)cyclopentane-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride; copper(l) iodide / N,N-dimethyl-formamide / 1 h / 110 °C / Inert atmosphere; Microwave irradiation

2: N-chloro-succinimide; silver(I) acetate / acetone / Reflux

3: hydrogenchloride / acetone; water / 2 h / 60 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-chloro-succinimide; copper(l) iodide; silver(I) acetate; cesium fluoride; In water; N,N-dimethyl-formamide; acetone;