3-[(3R)-3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-9-yl]benzonitrile hydrochloride

Base Information

Chemical Name:3-[(3R)-3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-9-yl]benzonitrile hydrochloride
CAS No.:958489-77-5
Molecular Formula:C₁₆H₁₃N₃OS*ClH
Molecular Weight:331.826
Hs Code.:

Synonyms:3-[(3R)-3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-9-yl]benzonitrile hydrochloride

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Chemical Property of 3-[(3R)-3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-9-yl]benzonitrile hydrochloride

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Technology Process of 3-[(3R)-3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-9-yl]benzonitrile hydrochloride

There total 6 articles about 3-[(3R)-3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-9-yl]benzonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 958489-76-4
3-[(3R)-3-{(1,1-dimethylethoxycarbonyl)amino}-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-9-yl]benzonitrile

: 958489-77-5
3-[(3R)-3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-9-yl]benzonitrile hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 4h;

Reference yield:

: 958489-74-2
S-(3'-cyano-3-nitrobiphenyl-2-yl)-N-(1,1-dimethylethoxycarbonyl)-L-cysteine

: 958489-77-5
3-[(3R)-3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-9-yl]benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / 10 h / 20 °C / 5250.53 Torr

2.1: diethyl cyanophosphonate / N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 2 h / 0 °C

3.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; diethyl cyanophosphonate; hydrogen; palladium 10% on activated carbon; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 958489-73-1
2'-fluoro-3'-nitrobiphenyl-3-carbonitrile

: 958489-77-5
3-[(3R)-3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-9-yl]benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / ethanol; water / 2 h / Heating / reflux

2.1: hydrogen / palladium 10% on activated carbon / 10 h / 20 °C / 5250.53 Torr

3.1: diethyl cyanophosphonate / N,N-dimethyl-formamide / 0.17 h / 0 °C

3.2: 2 h / 0 °C

4.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; diethyl cyanophosphonate; hydrogen; sodium hydrogencarbonate; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;