(+)-(2S,3S,1'S)-3-amino-N-(1-hydroxymethyl-2-methylpropyl)-2-ethyl-2-methyl-3-phenylpropanamide

Base Information

Chemical Name:(+)-(2S,3S,1'S)-3-amino-N-(1-hydroxymethyl-2-methylpropyl)-2-ethyl-2-methyl-3-phenylpropanamide
CAS No.:1000856-62-1
Molecular Formula:C₁₇H₂₈N₂O₂
Molecular Weight:292.422
Hs Code.:

Synonyms:(+)-(2S,3S,1'S)-3-amino-N-(1-hydroxymethyl-2-methylpropyl)-2-ethyl-2-methyl-3-phenylpropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(2S,3S,1'S)-3-amino-N-(1-hydroxymethyl-2-methylpropyl)-2-ethyl-2-methyl-3-phenylpropanamide

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Technology Process of (+)-(2S,3S,1'S)-3-amino-N-(1-hydroxymethyl-2-methylpropyl)-2-ethyl-2-methyl-3-phenylpropanamide

There total 3 articles about (+)-(2S,3S,1'S)-3-amino-N-(1-hydroxymethyl-2-methylpropyl)-2-ethyl-2-methyl-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: N-((S)-1-hydroxy-3-methylbut-2-yl)-2-methyl-2-(phenyl(phenylsulfonamido)methyl)butanamide

: 1000856-62-1
(+)-(2S,3S,1'S)-3-amino-N-(1-hydroxymethyl-2-methylpropyl)-2-ethyl-2-methyl-3-phenylpropanamide

Guidance literature:: With 4,4'-di-tert-butylbiphenyl; lithium; In tetrahydrofuran; at 0 ℃; for 3.5h;
DOI:10.1021/ol802643k

Reference yield: 90.0%

: C₂₃H₃₂N₂O₄S

: 1000856-62-1
(+)-(2S,3S,1'S)-3-amino-N-(1-hydroxymethyl-2-methylpropyl)-2-ethyl-2-methyl-3-phenylpropanamide

Guidance literature:: With lithium 4,4’-di-tert-butylbiphenylide; In tetrahydrofuran; at -78 ℃; for 3.5h;
DOI:10.1002/anie.201208792

Reference yield:

: C₁₀H₂₁NO

: 280555-20-6,910313-95-0
N-(2-phenylpropan-2-yl)-α-phenylnitrone

: 1000856-62-1
(+)-(2S,3S,1'S)-3-amino-N-(1-hydroxymethyl-2-methylpropyl)-2-ethyl-2-methyl-3-phenylpropanamide

Guidance literature:: C₁₀H₂₁NO; With sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 0.333333h;

N-(2-phenylpropan-2-yl)-α-phenylnitrone; In tetrahydrofuran; cyclohexane; at -78 - 20 ℃;

With hydrogen; palladium on activated charcoal; In methanol; at 25 ℃; for 16h; under 7500.75 Torr; Further stages.;
DOI:10.1016/j.tetlet.2007.10.035