methyl 2-[[(tert-butoxycarbonyl)amino](phenyl)methyl]-8-[[2-[3-[(1R,2R)-2-(dimethylamino)cyclohexyl]ureido]phenyl]ethynyl]-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Base Information

Chemical Name:methyl 2-[[(tert-butoxycarbonyl)amino](phenyl)methyl]-8-[[2-[3-[(1R,2R)-2-(dimethylamino)cyclohexyl]ureido]phenyl]ethynyl]-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate
CAS No.:1548422-23-6
Molecular Formula:C₄₁H₄₈N₄O₆
Molecular Weight:692.855
Hs Code.:

methyl 2-[[(tert-butoxycarbonyl)amino](phenyl)methyl]-8-[[2-[3-[(1R,2R)-2-(dimethylamino)cyclohexyl]ureido]phenyl]ethynyl]-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Synonyms:methyl 2-[[(tert-butoxycarbonyl)amino](phenyl)methyl]-8-[[2-[3-[(1R,2R)-2-(dimethylamino)cyclohexyl]ureido]phenyl]ethynyl]-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

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Chemical Property of methyl 2-[[(tert-butoxycarbonyl)amino](phenyl)methyl]-8-[[2-[3-[(1R,2R)-2-(dimethylamino)cyclohexyl]ureido]phenyl]ethynyl]-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

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Technology Process of methyl 2-[[(tert-butoxycarbonyl)amino](phenyl)methyl]-8-[[2-[3-[(1R,2R)-2-(dimethylamino)cyclohexyl]ureido]phenyl]ethynyl]-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

There total 6 articles about methyl 2-[[(tert-butoxycarbonyl)amino](phenyl)methyl]-8-[[2-[3-[(1R,2R)-2-(dimethylamino)cyclohexyl]ureido]phenyl]ethynyl]-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: methyl 8-[[2-[3-[(1R,2R)-2-(Dimethylamino)cyclohexyl]ureido]-phenyl]ethynyl]-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

: 150884-50-7
benzaldehyde N-boc imine

: 1548422-23-6
methyl 2-[[(tert-butoxycarbonyl)amino](phenyl)methyl]-8-[[2-[3-[(1R,2R)-2-(dimethylamino)cyclohexyl]ureido]phenyl]ethynyl]-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Guidance literature:: In dichloromethane-d2; at 20 ℃; for 0.166667h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo4028775

Reference yield:

: 1548421-99-3
1-[(1R,2R)-2-(dimethylamino)cyclohexyl]-3-(2-ethynylphenyl)-urea

: 1548422-23-6
methyl 2-[[(tert-butoxycarbonyl)amino](phenyl)methyl]-8-[[2-[3-[(1R,2R)-2-(dimethylamino)cyclohexyl]ureido]phenyl]ethynyl]-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: dichloromethane-d2 / 0.17 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; In tetrahydrofuran; dichloromethane-d2; 1: |Sonogashira Cross-Coupling / 2: |Mannich Aminomethylation;
DOI:10.1021/jo4028775

Reference yield:

: 1548422-05-4
methyl 8-iodo-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

: 1548422-23-6
methyl 2-[[(tert-butoxycarbonyl)amino](phenyl)methyl]-8-[[2-[3-[(1R,2R)-2-(dimethylamino)cyclohexyl]ureido]phenyl]ethynyl]-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: dichloromethane-d2 / 0.17 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; In tetrahydrofuran; dichloromethane-d2; 1: |Sonogashira Cross-Coupling / 2: |Mannich Aminomethylation;
DOI:10.1021/jo4028775