1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)piperidine-4-carboxylic acid

Base Information

Chemical Name:1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)piperidine-4-carboxylic acid
CAS No.:1621065-22-2
Molecular Formula:C₂₈H₃₉NO₃
Molecular Weight:437.623
Hs Code.:

Synonyms:1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)piperidine-4-carboxylic acid

Suppliers and Price of 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)piperidine-4-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)piperidine-4-carboxylic acid

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)piperidine-4-carboxylic acid

There total 8 articles about 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1621065-23-3
ethyl 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)piperidine-4-carboxylate

: 1621065-22-2
1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)piperidine-4-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 20 ℃; for 2h;
DOI:10.1021/acsmedchemlett.0c00631

Reference yield:

: 57404-87-2
3-methoxy-1-methylnaphthalene

: 1621065-22-2
1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron trichloride; tetra-(n-butyl)ammonium iodide / dichloromethane / 1 h / -78 - 0 °C / Inert atmosphere

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / Reflux

3.1: tin(IV) chloride / 1,2-dichloro-ethane / 1 h / 0 °C

3.2: 2 h / 0 - 20 °C

3.3: 1 h

4.1: ethanol / 2 h / Reflux

4.2: Reflux

5.1: water; lithium hydroxide / methanol; tetrahydrofuran / 1 h / 20 °C

With di-isopropyl azodicarboxylate; water; boron trichloride; tin(IV) chloride; tetra-(n-butyl)ammonium iodide; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 26207-06-7
4-methylnaphthalen-2-ol

: 1621065-22-2
1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / tert-butyl alcohol; butanone / 80 °C

2.1: tin(IV) chloride / 1,2-dichloro-ethane / 1 h / 0 °C

2.2: 2 h / 0 - 20 °C

2.3: 1 h

3.1: ethanol / 2 h / Reflux

3.2: Reflux

4.1: water; lithium hydroxide / methanol; tetrahydrofuran / 1 h / 20 °C

With water; tin(IV) chloride; caesium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; 1,2-dichloro-ethane; butanone; tert-butyl alcohol;