(2R,3S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(3-perylen-3-yl-propoxy)-tetrahydro-furan-3-ol

Base Information

Chemical Name:(2R,3S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(3-perylen-3-yl-propoxy)-tetrahydro-furan-3-ol
CAS No.:830346-93-5
Molecular Formula:C₄₉H₄₄O₆
Molecular Weight:728.885
Hs Code.:

Synonyms:(2R,3S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(3-perylen-3-yl-propoxy)-tetrahydro-furan-3-ol

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Chemical Property of (2R,3S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(3-perylen-3-yl-propoxy)-tetrahydro-furan-3-ol

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Technology Process of (2R,3S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(3-perylen-3-yl-propoxy)-tetrahydro-furan-3-ol

There total 5 articles about (2R,3S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(3-perylen-3-yl-propoxy)-tetrahydro-furan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 830346-90-2
(2R,3S,5S)-2-Hydroxymethyl-5-(3-perylen-3-yl-propoxy)-tetrahydro-furan-3-ol

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 830346-93-5
(2R,3S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(3-perylen-3-yl-propoxy)-tetrahydro-furan-3-ol

Guidance literature:: With pyridine; for 21h;
DOI:10.1039/b410695d

Reference yield:

: 23683-68-3
3-bromoperylene

: 830346-93-5
(2R,3S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(3-perylen-3-yl-propoxy)-tetrahydro-furan-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 66 percent / piperidine; CuI / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 2 h / 70 °C

2: 84 percent / H₂ / Pd/C / tetrahydrofuran / 15 h

3: 417 mg / ZnBr₂; NaHCO₃; 4 Angstroem molecular sieves / tetrahydrofuran / 4 h / 20 °C

4: 89 percent / NaOMe / methanol; CH₂Cl₂ / 15 h

5: 74 percent / pyridine / 21 h

With piperidine; pyridine; copper(l) iodide; 4 A molecular sieve; hydrogen; sodium methylate; sodium hydrogencarbonate; zinc dibromide; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; 1: Sonogashira coupling;
DOI:10.1039/b410695d

Reference yield:

: 830346-81-1
3-(3-hydroxy-1-propynyl)perylene

: 830346-93-5
(2R,3S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(3-perylen-3-yl-propoxy)-tetrahydro-furan-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / H₂ / Pd/C / tetrahydrofuran / 15 h

2: 417 mg / ZnBr₂; NaHCO₃; 4 Angstroem molecular sieves / tetrahydrofuran / 4 h / 20 °C

3: 89 percent / NaOMe / methanol; CH₂Cl₂ / 15 h

4: 74 percent / pyridine / 21 h

With pyridine; 4 A molecular sieve; hydrogen; sodium methylate; sodium hydrogencarbonate; zinc dibromide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/b410695d