methyl 2-<1-(benzesulfonylpyrrol-2-yl)methyl>amino-3,3-diethoxybutyrate

Base Information

• Chemical Name: methyl 2-<1-(benzesulfonylpyrrol-2-yl)methyl>amino-3,3-diethoxybutyrate
• CAS No.: 234430-84-3
• Molecular Formula: C₂₀H₂₈N₂O₆S
• Molecular Weight: 424.518
• Mol file: 234430-84-3.mol

Synonyms:methyl 2-<1-(benzesulfonylpyrrol-2-yl)methyl>amino-3,3-diethoxybutyrate

Chemical Property of methyl 2-<1-(benzesulfonylpyrrol-2-yl)methyl>amino-3,3-diethoxybutyrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-<1-(benzesulfonylpyrrol-2-yl)methyl>amino-3,3-diethoxybutyrate

There total 2 articles about methyl 2-<1-(benzesulfonylpyrrol-2-yl)methyl>amino-3,3-diethoxybutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-{[1-(1-Benzenesulfonyl-1H-pyrrol-2-yl)-meth-(E)-ylidene]-amino}-3,3-diethoxy-butyric acid methyl ester (234430-85-4) → methyl 2-<1-(benzesulfonylpyrrol-2-yl)methyl>amino-3,3-diethoxybutyrate (234430-84-3)

Guidance literature:

With sodium cyanoborohydride; In ethanol; for 0.833333h; Ambient temperature;

DOI:10.1016/S0968-0896(99)00053-X

Reference yield:

methyl 2-amino-3,3-diethoxybutyrate (156571-72-1) → methyl 2-<1-(benzesulfonylpyrrol-2-yl)methyl>amino-3,3-diethoxybutyrate (234430-84-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / Et₃N, 4 Angstroem MS / CH₂Cl₂ / 36 h / Ambient temperature

2: 98 percent / NaBH₃CN / ethanol / 0.83 h / Ambient temperature

With 4 Angstroem MS; sodium cyanoborohydride; triethylamine; In ethanol; dichloromethane;

DOI:10.1016/S0968-0896(99)00053-X

Reference yield: 68.0%

methyl 2-<1-(benzesulfonylpyrrol-2-yl)methyl>amino-3,3-diethoxybutyrate (234430-84-3) → methyl 1-benzesulfonyl-4-methylpyrrolo<2,3-c>-pyridine-5-carboxylate (234430-86-5)

Guidance literature:

With titanium tetrachloride; In benzene; for 2h; Heating;

DOI:10.1016/S0968-0896(99)00053-X

upstream raw materials:

2-{[1-(1-Benzenesulfonyl-1H-pyrrol-2-yl)-meth-(E)-ylidene]-amino}-3,3-diethoxy-butyric acid methyl ester

methyl 2-amino-3,3-diethoxybutyrate

Downstream raw materials:

methyl 1-benzesulfonyl-4-methylpyrrolo<2,3-c>-pyridine-5-carboxylate

methyl 1-benzesulfonyl-4-bromomethylpyrrolo<2,3-c>-pyridine-5-carboxylate