N-[2-(2-chloro-5-fluorophenoxy)ethyl]-1-[2-(methylsulfonyl)phenyl]ethanamine hydrochloride

Base Information

Chemical Name:N-[2-(2-chloro-5-fluorophenoxy)ethyl]-1-[2-(methylsulfonyl)phenyl]ethanamine hydrochloride
CAS No.:1256725-49-1
Molecular Formula:C₁₇H₁₉ClFNO₃S*ClH
Molecular Weight:408.321
Hs Code.:

Synonyms:N-[2-(2-chloro-5-fluorophenoxy)ethyl]-1-[2-(methylsulfonyl)phenyl]ethanamine hydrochloride

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Chemical Property of N-[2-(2-chloro-5-fluorophenoxy)ethyl]-1-[2-(methylsulfonyl)phenyl]ethanamine hydrochloride

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Technology Process of N-[2-(2-chloro-5-fluorophenoxy)ethyl]-1-[2-(methylsulfonyl)phenyl]ethanamine hydrochloride

There total 2 articles about N-[2-(2-chloro-5-fluorophenoxy)ethyl]-1-[2-(methylsulfonyl)phenyl]ethanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 2-(2-chloro-5-fluorophenoxy)-N-{1-[2-(methylsulfonyl)phenyl]ethyl}acetamide

: 1256725-49-1
N-[2-(2-chloro-5-fluorophenoxy)ethyl]-1-[2-(methylsulfonyl)phenyl]ethanamine hydrochloride

Guidance literature:: 2-(2-chloro-5-fluorophenoxy)-N-{1-[2-(methylsulfonyl)phenyl]ethyl}acetamide; With borane-THF; In tetrahydrofuran; at 0 ℃; for 2h; Heating;

With hydrogenchloride; In tetrahydrofuran; ethyl acetate; at 70 ℃; for 2h;
DOI:10.1016/j.ejmech.2017.07.071

Reference yield:

: C₉H₁₃NO₂S

: 451-19-4
(2-chloro-5-fluoro-phenoxy)-acetic acid

: 1256725-49-1
N-[2-(2-chloro-5-fluorophenoxy)ethyl]-1-[2-(methylsulfonyl)phenyl]ethanamine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2-[2-(methylsulfanyl)phenyl]acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 2 h / 20 °C

2.1: borane-THF / tetrahydrofuran / 2 h / 0 °C / Heating

2.2: 2 h / 70 °C

With borane-THF; 2-[2-(methylsulfanyl)phenyl]acetic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.ejmech.2017.07.071