methyl (-)-{(3R,4R,5S)-3-[tert-butyl(dimethyl)silyl]oxy-5-methoxy-4-[(4-methoxyphenyl)amino]piperidin-1-yl}acetate

Base Information

Chemical Name:methyl (-)-{(3R,4R,5S)-3-[tert-butyl(dimethyl)silyl]oxy-5-methoxy-4-[(4-methoxyphenyl)amino]piperidin-1-yl}acetate
CAS No.:956428-97-0
Molecular Formula:C₂₂H₃₈N₂O₅Si
Molecular Weight:438.64
Hs Code.:

Synonyms:methyl (-)-{(3R,4R,5S)-3-[tert-butyl(dimethyl)silyl]oxy-5-methoxy-4-[(4-methoxyphenyl)amino]piperidin-1-yl}acetate

Suppliers and Price of methyl (-)-{(3R,4R,5S)-3-[tert-butyl(dimethyl)silyl]oxy-5-methoxy-4-[(4-methoxyphenyl)amino]piperidin-1-yl}acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (-)-{(3R,4R,5S)-3-[tert-butyl(dimethyl)silyl]oxy-5-methoxy-4-[(4-methoxyphenyl)amino]piperidin-1-yl}acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (-)-{(3R,4R,5S)-3-[tert-butyl(dimethyl)silyl]oxy-5-methoxy-4-[(4-methoxyphenyl)amino]piperidin-1-yl}acetate

There total 4 articles about methyl (-)-{(3R,4R,5S)-3-[tert-butyl(dimethyl)silyl]oxy-5-methoxy-4-[(4-methoxyphenyl)amino]piperidin-1-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 956428-93-6
(-)-(3R,4R,5R)-5-[tert-butyl(dimethyl)silyl]oxy-3-methoxy-4-[(4-methoxyphenyl)amino]piperidin-2-one

: 96-32-2
bromoacetic acid methyl ester

: 956428-97-0
methyl (-)-{(3R,4R,5S)-3-[tert-butyl(dimethyl)silyl]oxy-5-methoxy-4-[(4-methoxyphenyl)amino]piperidin-1-yl}acetate

Guidance literature:: (-)-(3R,4R,5R)-5-[tert-butyl(dimethyl)silyl]oxy-3-methoxy-4-[(4-methoxyphenyl)amino]piperidin-2-one; With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃;

bromoacetic acid methyl ester; With potassium carbonate; lithium iodide; In acetonitrile; at 20 ℃; for 3h; Further stages.;
DOI:10.1021/jo701452a

Reference yield:

: 956428-49-2
(+)-(2S)-[tert-butyl(dimethyl)silyloxy][(2R,3R)-3-methoxy-1-(4-methoxyphenyl)-4-oxoazetidin-2-yl]acetonitrile

: 956428-97-0
methyl (-)-{(3R,4R,5S)-3-[tert-butyl(dimethyl)silyl]oxy-5-methoxy-4-[(4-methoxyphenyl)amino]piperidin-1-yl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / sodium borohydride; nickel(II) chloride hexahydrate / methanol / 0 - 20 °C

2.1: 72 percent / sodium methoxide / methanol / 8 h / Heating

3.1: LiAlH₄ / diethyl ether / 0 - 20 °C

3.2: 50 percent / potassium carbonate; lithium iodide / acetonitrile / 3 h / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; sodium methylate; nickel dichloride; In methanol; diethyl ether;
DOI:10.1021/jo701452a

Reference yield:

: 956428-59-4
(+)-(3R,4R)-4-((1R)-2-amino-1-[tert-butyl(dimethyl)silyloxy]ethyl)-3-methoxy-1-(4-methoxyphenyl)azetidin-2-one

: 956428-97-0
methyl (-)-{(3R,4R,5S)-3-[tert-butyl(dimethyl)silyl]oxy-5-methoxy-4-[(4-methoxyphenyl)amino]piperidin-1-yl}acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 72 percent / sodium methoxide / methanol / 8 h / Heating

2.1: LiAlH₄ / diethyl ether / 0 - 20 °C

2.2: 50 percent / potassium carbonate; lithium iodide / acetonitrile / 3 h / 20 °C

With lithium aluminium tetrahydride; sodium methylate; In methanol; diethyl ether;
DOI:10.1021/jo701452a