tert.-butyl (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-4-methyl-n-pentyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate

Base Information

Chemical Name:tert.-butyl (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-4-methyl-n-pentyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate
CAS No.:89371-60-8
Molecular Formula:C₃₂H₄₃N₃O₆
Molecular Weight:565.71
Hs Code.:

Synonyms:tert.-butyl (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-4-methyl-n-pentyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate

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Chemical Property of tert.-butyl (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-4-methyl-n-pentyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate

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Technology Process of tert.-butyl (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-4-methyl-n-pentyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate

There total 3 articles about tert.-butyl (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-4-methyl-n-pentyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77999-24-7
(S)‐2‐oxoimidazolidine‐1,5‐dicarboxylate-5‐tert‐butyl ester-1‐benzyl ester

: 89371-60-8
tert.-butyl (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-4-methyl-n-pentyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 75.6 percent / K₂CO₃ / acetone / Ambient temperature

2: 94.3 percent / H₂ / Pd / methanol / 3 h / 760 Torr / Ambient temperature

3: 1) KOtBu / 1) THF, -50 deg C, 20 min, 2) -30 deg C, 1 h

4: 18.9 percent / K₂CO₃ / hexamethylphosphoric acid triamide / 48 h / Ambient temperature

With potassium tert-butylate; hydrogen; potassium carbonate; palladium; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; acetone;
DOI:10.1021/jm00122a003

Reference yield:

: 83057-00-5
(S)-3-benzyl-2-oxo-imidazolidine-1,5-dicarboxylic acid 1-benzyl ester 5-t-butyl ester

: 89371-60-8
tert.-butyl (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-4-methyl-n-pentyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 94.3 percent / H₂ / Pd / methanol / 3 h / 760 Torr / Ambient temperature

2: 1) KOtBu / 1) THF, -50 deg C, 20 min, 2) -30 deg C, 1 h

3: 18.9 percent / K₂CO₃ / hexamethylphosphoric acid triamide / 48 h / Ambient temperature

With potassium tert-butylate; hydrogen; potassium carbonate; palladium; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/jm00122a003

Reference yield:

: 83057-01-6
tert.-butyl (4S)-1-benzyl-2-oxo-imidazolidine-4-carboxylate

: 89371-60-8
tert.-butyl (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-4-methyl-n-pentyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1) KOtBu / 1) THF, -50 deg C, 20 min, 2) -30 deg C, 1 h

2: 18.9 percent / K₂CO₃ / hexamethylphosphoric acid triamide / 48 h / Ambient temperature

With potassium tert-butylate; potassium carbonate; In N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/jm00122a003