(1R,2S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-1-methylene-butyl]-5-oxo-cyclopentanecarboxylic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

Base Information

Chemical Name:(1R,2S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-1-methylene-butyl]-5-oxo-cyclopentanecarboxylic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester
CAS No.:187869-71-2
Molecular Formula:C₅₃H₆₇NO₆SSi
Molecular Weight:874.27
Hs Code.:

(1R,2S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-1-methylene-butyl]-5-oxo-cyclopentanecarboxylic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

Synonyms:(1R,2S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-1-methylene-butyl]-5-oxo-cyclopentanecarboxylic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

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Chemical Property of (1R,2S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-1-methylene-butyl]-5-oxo-cyclopentanecarboxylic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

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Technology Process of (1R,2S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-1-methylene-butyl]-5-oxo-cyclopentanecarboxylic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

There total 5 articles about (1R,2S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-1-methylene-butyl]-5-oxo-cyclopentanecarboxylic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 174757-25-6
5-Oxo-cyclopent-1-enecarboxylic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

: 187869-50-7
(4-Bromo-3,3-dimethyl-pent-4-enyloxy)-tert-butyl-diphenyl-silane

: 187869-71-2
(1R,2S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-1-methylene-butyl]-5-oxo-cyclopentanecarboxylic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: With n-butyllithium; copper(I) bromide dimethylsulfide complex; magnesium bromide; In tetrahydrofuran; pentane; at -78 ℃; for 3h;
DOI:10.1002/hlca.19970800114

Reference yield:

: 139897-19-1
(2-bromoethoxy)(tert-butyl)diphenylsilane

: 187869-71-2
(1R,2S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-1-methylene-butyl]-5-oxo-cyclopentanecarboxylic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / (i-Pr)2NH, BuLi / hexane; tetrahydrofuran / 96 h / Ambient temperature

2: 75 percent / piperidine, BuLi / hexane; diethyl ether / 12 h / Ambient temperature

3: 63 percent / BuLi / hexane; diethyl ether / 3 h / 0 °C

4: 68 percent / B-bromo-9-borabicyclo<3.3.1>nonane / CH₂Cl₂ / 2.5 h / 0 °C

5: 70 percent / BuLi, MgBr*Et₂O, CuBr*MeS₂ / pentane; tetrahydrofuran / 3 h / -78 °C

With piperidine; n-butyllithium; copper(I) bromide dimethylsulfide complex; 9-bromo-9-bora-bicyclo[3.3.1]nonane; diisopropylamine; magnesium bromide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; pentane;
DOI:10.1002/hlca.19970800114

Reference yield:

: 187869-66-5
tert-Butyl-(3,3-dimethyl-pent-4-ynyloxy)-diphenyl-silane

: 187869-71-2
(1R,2S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-1-methylene-butyl]-5-oxo-cyclopentanecarboxylic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / B-bromo-9-borabicyclo<3.3.1>nonane / CH₂Cl₂ / 2.5 h / 0 °C

2: 70 percent / BuLi, MgBr*Et₂O, CuBr*MeS₂ / pentane; tetrahydrofuran / 3 h / -78 °C

With n-butyllithium; copper(I) bromide dimethylsulfide complex; 9-bromo-9-bora-bicyclo[3.3.1]nonane; magnesium bromide; In tetrahydrofuran; dichloromethane; pentane;
DOI:10.1002/hlca.19970800114