(1S,4aS,5S,6R,8aS)-5-(2-Chloro-3,5-dimethoxy-benzyl)-6-hydroxymethyl-5,8a-dimethyl-decahydro-naphthalen-1-ol

Base Information

Chemical Name:(1S,4aS,5S,6R,8aS)-5-(2-Chloro-3,5-dimethoxy-benzyl)-6-hydroxymethyl-5,8a-dimethyl-decahydro-naphthalen-1-ol
CAS No.:188477-58-9
Molecular Formula:C₂₂H₃₃ClO₄
Molecular Weight:396.955
Hs Code.:

Synonyms:(1S,4aS,5S,6R,8aS)-5-(2-Chloro-3,5-dimethoxy-benzyl)-6-hydroxymethyl-5,8a-dimethyl-decahydro-naphthalen-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,4aS,5S,6R,8aS)-5-(2-Chloro-3,5-dimethoxy-benzyl)-6-hydroxymethyl-5,8a-dimethyl-decahydro-naphthalen-1-ol

Chemical Property:

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Technology Process of (1S,4aS,5S,6R,8aS)-5-(2-Chloro-3,5-dimethoxy-benzyl)-6-hydroxymethyl-5,8a-dimethyl-decahydro-naphthalen-1-ol

There total 1 articles about (1S,4aS,5S,6R,8aS)-5-(2-Chloro-3,5-dimethoxy-benzyl)-6-hydroxymethyl-5,8a-dimethyl-decahydro-naphthalen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 162407-17-2
(1S,4aS,5S,8aS)-5-(2-Chloro-3,5-dimethoxy-benzyl)-5,8a-dimethyl-6-methylene-decahydro-naphthalen-1-ol

: 188477-58-9
(1S,4aS,5S,6R,8aS)-5-(2-Chloro-3,5-dimethoxy-benzyl)-6-hydroxymethyl-5,8a-dimethyl-decahydro-naphthalen-1-ol

: 188477-59-0
(1S,4aS,5S,6S,8aS)-5-(2-Chloro-3,5-dimethoxy-benzyl)-6-hydroxymethyl-5,8a-dimethyl-decahydro-naphthalen-1-ol

Guidance literature:: With sodium hydroxide; dimethylsulfide borane complex; dihydrogen peroxide; Yield given. Multistep reaction. Yields of byproduct given; 1) THF, reflux, 3 h; 2) THF, EtOH, rt, 1 h;
DOI:10.1021/jo962292l

Reference yield:

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 188477-58-9
(1S,4aS,5S,6R,8aS)-5-(2-Chloro-3,5-dimethoxy-benzyl)-6-hydroxymethyl-5,8a-dimethyl-decahydro-naphthalen-1-ol

: 188477-61-4
6-tert-Butoxycarbonylamino-hexanoic acid (1S,2R,4aS,5S,8aS)-1-(2-chloro-3,5-dimethoxy-benzyl)-5-hydroxy-1,4a-dimethyl-decahydro-naphthalen-2-ylmethyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/jo962292l

Reference yield:

: 188477-58-9
(1S,4aS,5S,6R,8aS)-5-(2-Chloro-3,5-dimethoxy-benzyl)-6-hydroxymethyl-5,8a-dimethyl-decahydro-naphthalen-1-ol

: 188477-65-8
6-tert-Butoxycarbonylamino-hexanoic acid (1S,2R,4aS,8aS)-1-(2-chloro-3,5-dimethoxy-benzyl)-1,4a-dimethyl-5-methylene-decahydro-naphthalen-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: DMAP, EDCI / CH₂Cl₂

2: PCC / CH₂Cl₂ / Ambient temperature

3: dimethylsulfoxide

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridinium chlorochromate; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo962292l