(R)-methyl 4-(1-(1-(4-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoate

Base Information

Chemical Name:(R)-methyl 4-(1-(1-(4-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoate
CAS No.:1417744-14-9
Molecular Formula:C₂₅H₂₇F₃N₂O₃
Molecular Weight:460.496
Hs Code.:

Synonyms:(R)-methyl 4-(1-(1-(4-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoate

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Chemical Property of (R)-methyl 4-(1-(1-(4-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoate

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Technology Process of (R)-methyl 4-(1-(1-(4-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoate

There total 5 articles about (R)-methyl 4-(1-(1-(4-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1417560-94-1
methyl (R)-4-(1-(piperidine-2- carboxamido)cyclopropyl)benzoate

: 402-49-3
4-bromomethyltrifluoromethylbenzene

: 1417744-14-9
(R)-methyl 4-(1-(1-(4-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoate

Guidance literature:: With caesium carbonate; In tetrahydrofuran; for 24h;

Reference yield:

: 1417560-87-2
tert-butyl (R)-2-((1-(4- (methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)piperidine-1-carboxylate

: 1417744-14-9
(R)-methyl 4-(1-(1-(4-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

2: caesium carbonate / tetrahydrofuran / 24 h

With caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1006037-03-1
4-(1-aminocyclopropyl)-benzoic acid methyl ester

: 1417744-14-9
(R)-methyl 4-(1-(1-(4-(trifluoromethyl)benzyl)piperidine-2-carboxamido)cyclopropyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.67 h

1.2: 15 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

3.1: caesium carbonate / tetrahydrofuran / 24 h

With benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;