(1'R)-2-[1'-(benzyloxycarbonyl) amino]ethyl-3-methoxycarbonylindole

Base Information

• Chemical Name: (1'R)-2-[1'-(benzyloxycarbonyl) amino]ethyl-3-methoxycarbonylindole
• CAS No.: 1586809-86-0
• Molecular Formula: C₂₀H₂₀N₂O₄
• Molecular Weight: 352.39
• Mol file: 1586809-86-0.mol

Synonyms:(1'R)-2-[1'-(benzyloxycarbonyl) amino]ethyl-3-methoxycarbonylindole

Chemical Property of (1'R)-2-[1'-(benzyloxycarbonyl) amino]ethyl-3-methoxycarbonylindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1'R)-2-[1'-(benzyloxycarbonyl) amino]ethyl-3-methoxycarbonylindole

There total 8 articles about (1'R)-2-[1'-(benzyloxycarbonyl) amino]ethyl-3-methoxycarbonylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

C21H17F3N2O5 (1586809-83-7) → (1'R)-2-[1'-(benzyloxycarbonyl) amino]ethyl-3-methoxycarbonylindole (1586809-86-0)

Guidance literature:

With hydrogenchloride; In methanol; water; at 80 ℃; for 2h;

DOI:10.1016/j.tetlet.2014.02.059

Reference yield:

C22H21F3N2O6 → (1'R)-2-[1'-(benzyloxycarbonyl) amino]ethyl-3-methoxycarbonylindole (1586809-86-0)

Guidance literature:

With hydrogenchloride; In methanol; water; at 80 ℃; for 2h;

DOI:10.1016/j.tetlet.2014.02.059

Reference yield:

(4S)-methyl 4-(benzyloxycarbonyl)amino-3-hydroxy-2-(2-trifluoroacetamido)phenyl-2-pentenoate → (1'S)-2-[1'-(benzyloxycarbonyl) amino]ethyl-3-methoxycarbonylindole (1586809-85-9) + (1'R)-2-[1'-(benzyloxycarbonyl) amino]ethyl-3-methoxycarbonylindole (1586809-86-0)

Guidance literature:

With hydrogenchloride; In methanol; water; at 80 ℃; for 2h; Overall yield = 63 %; Overall yield = 38 mg;

DOI:10.1016/j.tetlet.2014.02.059

upstream raw materials:

methyl (S)-4-{[(benzyloxy)carbonyl]amino}-3-oxopentanoate

2,2,2-trifluoro-N-(2-iodophenyl)acetamide

(5S)-1-benzyloxycarbonyl-4-hydroxy-5-methyl-3-(2-trifluoroacetamido)phenyl-3-pyrrolin-2-one

(R)-4-Benzyloxycarbonylamino-3-oxo-pentanoic acid methyl ester