2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)acetamide

Base Information

Chemical Name:2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)acetamide
CAS No.:910811-18-6
Molecular Formula:C₂₄H₂₉NO₃S
Molecular Weight:411.565
Hs Code.:

Synonyms:2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)acetamide

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Chemical Property of 2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)acetamide

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Technology Process of 2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)acetamide

There total 12 articles about 2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 910814-48-1
2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)acetic acid

: 910811-18-6
2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)acetamide

Guidance literature:: 2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)acetic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

With ammonia; In methanol; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;
DOI:10.1021/jm4014373

Reference yield:

: 498-15-7,19079-29-9
(+)-Δ³-carene

: 910811-18-6
2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)acetamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: ozone / methanol / -65 °C

1.2: 2 h / 20 - 35 °C

2.1: thionyl chloride / 0.5 h / 0 °C

3.1: sodium methylate / methanol / 1 h / Reflux

4.1: triphenylphosphine; tetrachloromethane / tetrachloromethane / 65 °C

5.1: sodium ethanolate / ethanol / 0.08 h / 20 °C

5.2: 1 h / 20 °C

5.3: 1 h / 75 °C

6.1: lithium hydroxide; water / ethanol / 2 h / 75 °C

7.1: diethyl ether / 35 °C

8.1: hydrogenchloride / ethanol; isopropyl alcohol / 20 h / 20 °C

9.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 3 h / 20 °C / 1125.11 Torr

10.1: water; isopropyl alcohol / 70 °C

11.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

11.2: 0.5 h / 20 °C

With hydrogenchloride; tetrachloromethane; thionyl chloride; palladium 10% on activated carbon; water; hydrogen; sodium methylate; sodium ethanolate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; ozone; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; 3.1: |Dieckmann Condensation;
DOI:10.1021/jm4014373

Reference yield:

: 58930-63-5
(3¹R,3³S)-3²,3²-dimethyl-3(1,3)cyclopropyla-5-oxohexanoic acid

: 910811-18-6
2-(2,6-dimethyl-4-(3-oxo-3-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)propyl)phenoxy)acetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: thionyl chloride / 0.5 h / 0 °C

2.1: sodium methylate / methanol / 1 h / Reflux

3.1: triphenylphosphine; tetrachloromethane / tetrachloromethane / 65 °C

4.1: sodium ethanolate / ethanol / 0.08 h / 20 °C

4.2: 1 h / 20 °C

4.3: 1 h / 75 °C

5.1: lithium hydroxide; water / ethanol / 2 h / 75 °C

6.1: diethyl ether / 35 °C

7.1: hydrogenchloride / ethanol; isopropyl alcohol / 20 h / 20 °C

8.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 3 h / 20 °C / 1125.11 Torr

9.1: water; isopropyl alcohol / 70 °C

10.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

10.2: 0.5 h / 20 °C

With hydrogenchloride; tetrachloromethane; thionyl chloride; palladium 10% on activated carbon; water; hydrogen; sodium methylate; sodium ethanolate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; 2.1: |Dieckmann Condensation;
DOI:10.1021/jm4014373