N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-(tert-butoxycarbonyl)-L-lysine tert-butyl ester

Base Information

• Chemical Name: N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-(tert-butoxycarbonyl)-L-lysine tert-butyl ester
• CAS No.: 83399-36-4
• Molecular Formula: C₃₀H₄₃N₉O₅
• Molecular Weight: 609.729
• Mol file: 83399-36-4.mol

Synonyms:N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-(tert-butoxycarbonyl)-L-lysine tert-butyl ester

Chemical Property of N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-(tert-butoxycarbonyl)-L-lysine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-(tert-butoxycarbonyl)-L-lysine tert-butyl ester

There total 1 articles about N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-(tert-butoxycarbonyl)-L-lysine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.1%

4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid (19741-14-1) + 1,1-dimethylethyl N6-{[(1,1-dimethylethyl)oxy]carbonyl}-L-lysinate hydrochloride (13288-57-8) → Nα-(4-amino-4-deoxy-N10-methylpteroyl)-Nε-(tert-butoxycarbonyl)-L-lysine tert-butyl ester (83399-36-4)

Guidance literature:

With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; at 0 - 23 ℃; for 20.5h;

DOI:10.1021/jm00355a023

Reference yield:

Nα-(4-amino-4-deoxy-N10-methylpteroyl)-Nε-(tert-butoxycarbonyl)-L-lysine tert-butyl ester (83399-36-4) → Nα-(4-amino-4-deoxy-N10-methylpteroyl)-L-lysine (80407-56-3,246224-40-8)

Guidance literature:

With trifluoroacetic acid; In various solvent(s); for 4.5h; Ambient temperature;

DOI:10.1021/jm00355a023

upstream raw materials:

4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid

1,1-dimethylethyl N₆-{[(1,1-dimethylethyl)oxy]carbonyl}-L-lysinate hydrochloride

Downstream raw materials:

N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-lysine